ydaP
168
pyruvate:quinone oxidoreductases, general stress protein, required for survival of ethanol stress, cold stress (4°C) and oxidative stress (superoxide/paraquate)
Locus
BSU_04340
Molecular weight
62.97 kDa
Isoelectric point
5.22
Function
utilization of pyruvate
Product
pyruvate:quinone oxidoreductases
Essential
no
Synonyms
ydaP
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0028 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
488,830 490,554
Phenotypes of a mutant
sensitive to ethanol, cold (4C) and superoxide stress (paraquat)
The protein
Catalyzed reaction/ biological activity
pyruvate + menaquinone --> acetate + menaquinol + CO2 PubMed
Protein family
TPP enzyme family (according to UniProt)
Structure
4KGD (PDB) (the enzyme from Lactobacillus plantarum, 37% identity, 70% similarity) PubMed
1POW (PDB) (from Lactobacillus plantarum, 38% identity)
Paralogous protein(s)
peripheral membrane proteins bound to the cytoplasmatic side of the membrane PubMed
Expression and Regulation
Operons
Biological materials
Mutant
MGNA-C115 (ydaP::erm), available at the NBRP B. subtilis, Japan
GP457 (spc), available in Jörg Stülke's lab
JH642 and its derivatives: natural deletion of the 18 kb ydzA-mntH region encompassing the genes ydzA-topB-ydaJ-ydaK-ydaL-ydaM-ydaN-kimA-mutT-ydaP-ydzK-mntH PubMed
References
Reviews
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Original Publications
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Time of last update: 2025-04-03 10:43:25
Author of last update: Jstuelk