Difference between revisions of "HelP"

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* '''Description:''' similar to transposon protein <br/><br/>
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* '''Description:''' helicase processivity factor <br/><br/>
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{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
 
|-
 
|-
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|''ydcP''
 
|''ydcP''
 
|-
 
|-
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|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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|style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ydcP ''
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
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|style="background:#ABCDEF;" align="center"| '''Product''' || unknown
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|style="background:#ABCDEF;" align="center"| '''Product''' || helicase processivity factor
 +
|-
 +
|style="background:#ABCDEF;" align="center"|'''Function''' || conjugation and replication of ICEBs1
 
|-
 
|-
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|style="background:#ABCDEF;" align="center"|'''Function''' || unknown
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU04850 helP]
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 13 kDa, 5.309   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 13 kDa, 5.309   
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|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 378 bp, 126 aa  
 
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 378 bp, 126 aa  
 
|-
 
|-
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ydcO]]'', ''[[ydcQ]]''
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ydcO]]'', ''[[conQ]]''
 
|-
 
|-
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB12292&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
+
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU04850 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU04850 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU04850 DNA_with_flanks]
 
|-
 
|-
 
|colspan="2" | '''Genetic context''' <br/> [[Image:ydcP_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:ydcP_context.gif]]
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 
|-
 
|-
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|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ydcP_532922_533302_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:ydcP_expression.png|500px]]
+
|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ydcP_532922_533302_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:ydcP_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU04850]]
 
|-
 
|-
 
|}
 
|}
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<br/><br/><br/><br/>
 
<br/><br/><br/><br/>
 
<br/><br/><br/><br/>
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<br/><br/><br/><br/>
 
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<br/><br/><br/><br/>
 
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=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU04850&redirect=T BSU04850]
  
 
* '''DBTBS entry:''' no entry
 
* '''DBTBS entry:''' no entry
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* '''Catalyzed reaction/ biological activity:'''  
 
* '''Catalyzed reaction/ biological activity:'''  
−
 
+
** enables the host-encoded helicase [[PcrA]] to unwind the double-stranded ICEBs1 DNA {{PubMed|23326247}}
 
* '''Protein family:'''
 
* '''Protein family:'''
  
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* '''Kinetic information:'''
 
* '''Kinetic information:'''
  
−
* '''Domains:'''  
+
* '''[[Domains]]:'''  
  
 
* '''Modification:'''
 
* '''Modification:'''
  
−
* '''Cofactor(s):'''
+
* '''[[Cofactors]]:'''
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
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=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU04850&redirect=T BSU04850]
  
 
* '''Structure:'''
 
* '''Structure:'''
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* '''Operon:'''  
 
* '''Operon:'''  
  
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ydcP_532922_533302_1 ydcP] {{PubMed|22383849}}
+
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ydcP_532922_533302_1 helP] {{PubMed|22383849}}
  
−
* '''Sigma factor:'''  
+
* '''[[Sigma factor]]:'''  
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
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* '''Additional information:'''
 
* '''Additional information:'''
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** A [[ncRNA]] is predicted between ''[[ydcO]]'' and ''[[ydcP]]'' {{PubMed|20525796}}
+
** A [[ncRNA]] is predicted between ''[[ydcO]]'' and ''[[helP]]'' {{PubMed|20525796}}
  
 
=Biological materials =
 
=Biological materials =
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=References=
 
=References=
−
<pubmed>20525796</pubmed>
+
<pubmed>20525796 23326247 </pubmed>
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Latest revision as of 16:07, 28 May 2015

  • Description: helicase processivity factor

Gene name ydcP
Synonyms ydcP
Essential no
Product helicase processivity factor
Function conjugation and replication of ICEBs1
Gene expression levels in SubtiExpress: helP
MW, pI 13 kDa, 5.309
Gene length, protein length 378 bp, 126 aa
Immediate neighbours ydcO, conQ
Sequences Protein DNA DNA_with_flanks
Genetic context
YdcP context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YdcP expression.png















Categories containing this gene/protein

mobile genetic elements

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU04850

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • enables the host-encoded helicase PcrA to unwind the double-stranded ICEBs1 DNA PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Jacob Thomas, Catherine A Lee, Alan D Grossman
A conserved helicase processivity factor is needed for conjugation and replication of an integrative and conjugative element.
PLoS Genet: 2013, 9(1);e1003198
[PubMed:23326247] [WorldCat.org] [DOI] (I p)

Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796] [WorldCat.org] [DOI] (I p)

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