Difference between revisions of "OppC"
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= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| + | {{SubtiWiki regulon|[[CodY regulon]]}}, | ||
{{SubtiWiki regulon|[[ScoC regulon]]}}, | {{SubtiWiki regulon|[[ScoC regulon]]}}, | ||
{{SubtiWiki regulon|[[TnrA regulon]]}} | {{SubtiWiki regulon|[[TnrA regulon]]}} | ||
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=== Additional information=== | === Additional information=== | ||
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=The protein= | =The protein= | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=oppC_1222533_1223450_1 oppC] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=oppC_1222533_1223450_1 oppC] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' | * '''Regulation:''' | ||
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** [[TnrA]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/12823818 PubMed] | ** [[TnrA]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/12823818 PubMed] | ||
** [[ScoC]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10383984 PubMed] | ** [[ScoC]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10383984 PubMed] | ||
| + | ** [[CodY]]: transcription repression, no derepression occurs, however, in a ''[[codY]]'' mutant, due to increased repression by [[ScoC]] {{PubMed|25966844}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
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=Biological materials = | =Biological materials = | ||
| − | * '''Mutant:''' BP68 (spc) available in [[Fabian Commichau]]'s lab | + | * '''Mutant:''' |
| + | ** BP68 (spc) available in [[Fabian Commichau]]'s lab | ||
* '''Expression vector:''' | * '''Expression vector:''' | ||
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=References= | =References= | ||
| − | <pubmed>12823818,1901616,10092453,9252573,21908671,12823818,10383984, 7997159 1899858</pubmed> | + | <pubmed>12823818,1901616,10092453,9252573,21908671,12823818,10383984, 7997159 25966844 1899858</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 13:26, 15 May 2015
- Description: oligopeptide ABC transporter (permease)
| Gene name | oppC |
| Synonyms | spo0KC |
| Essential | no |
| Product | oligopeptide ABC transporter (permease) |
| Function | initiation of sporulation, competence development |
| Gene expression levels in SubtiExpress: oppC | |
| Interactions involving this protein in SubtInteract: OppC | |
| Metabolic function and regulation of this protein in SubtiPathways: oppC | |
| MW, pI | 33 kDa, 10.107 |
| Gene length, protein length | 915 bp, 305 aa |
| Immediate neighbours | oppB, oppD |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
ABC transporters, utilization of nitrogen sources other than amino acids, genetic competence, phosphorelay, membrane proteins
This gene is a member of the following regulons
CodY regulon, ScoC regulon, TnrA regulon
The gene
Basic information
- Locus tag: BSU11450
Phenotypes of a mutant
Database entries
- BsubCyc: BSU11450
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: ABC transmembrane type-1 domain (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane PubMed
Database entries
- BsubCyc: BSU11450
- Structure:
- UniProt: P24139
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- BP68 (spc) available in Fabian Commichau's lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Boris R Belitsky, Giulia Barbieri, Alessandra M Albertini, Eugenio Ferrari, Mark A Strauch, Abraham L Sonenshein
Interactive regulation by the Bacillus subtilis global regulators CodY and ScoC.
Mol Microbiol: 2015, 97(4);698-716
[PubMed:25966844]
[WorldCat.org]
[DOI]
(I p)
Nicolas Mirouze, Vijay Parashar, Melinda D Baker, David A Dubnau, Matthew B Neiditch
An atypical Phr peptide regulates the developmental switch protein RapH.
J Bacteriol: 2011, 193(22);6197-206
[PubMed:21908671]
[WorldCat.org]
[DOI]
(I p)
Ken-ichi Yoshida, Hirotake Yamaguchi, Masaki Kinehara, Yo-hei Ohki, Yoshiko Nakaura, Yasutaro Fujita
Identification of additional TnrA-regulated genes of Bacillus subtilis associated with a TnrA box.
Mol Microbiol: 2003, 49(1);157-65
[PubMed:12823818]
[WorldCat.org]
[DOI]
(P p)
A Koide, M Perego, J A Hoch
ScoC regulates peptide transport and sporulation initiation in Bacillus subtilis.
J Bacteriol: 1999, 181(13);4114-7
[PubMed:10383984]
[WorldCat.org]
[DOI]
(P p)
Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453]
[WorldCat.org]
[DOI]
(P p)
J R LeDeaux, J M Solomon, A D Grossman
Analysis of non-polar deletion mutations in the genes of the spo0K (opp) operon of Bacillus subtilis.
FEMS Microbiol Lett: 1997, 153(1);63-9
[PubMed:9252573]
[WorldCat.org]
[DOI]
(P p)
A Koide, J A Hoch
Identification of a second oligopeptide transport system in Bacillus subtilis and determination of its role in sporulation.
Mol Microbiol: 1994, 13(3);417-26
[PubMed:7997159]
[WorldCat.org]
[DOI]
(P p)
D Z Rudner, J R LeDeaux, K Ireton, A D Grossman
The spo0K locus of Bacillus subtilis is homologous to the oligopeptide permease locus and is required for sporulation and competence.
J Bacteriol: 1991, 173(4);1388-98
[PubMed:1899858]
[WorldCat.org]
[DOI]
(P p)
M Perego, C F Higgins, S R Pearce, M P Gallagher, J A Hoch
The oligopeptide transport system of Bacillus subtilis plays a role in the initiation of sporulation.
Mol Microbiol: 1991, 5(1);173-85
[PubMed:1901616]
[WorldCat.org]
[DOI]
(P p)
