Difference between revisions of "PgpH"
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|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Gene name''' | |style="background:#ABCDEF;" align="center"|'''Gene name''' | ||
| − | |'' | + | |''pgpH'' |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' '' | + | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yqfF '' |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
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|style="background:#ABCDEF;" align="center"|'''Function''' || control of c-di-AMP homeostasis | |style="background:#ABCDEF;" align="center"|'''Function''' || control of c-di-AMP homeostasis | ||
|- | |- | ||
| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU25330 | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU25330 pgpH] |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 78 kDa, 7.697 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 78 kDa, 7.697 | ||
| Line 86: | Line 86: | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| − | ** [[ | + | ** [[PgpH]] is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of [[SubtInteract|interactions]] {{PubMed|21630458}} |
* '''[[Localization]]:''' | * '''[[Localization]]:''' | ||
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* '''Operon:''' | * '''Operon:''' | ||
| − | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yqfF_2612282_2614417_-1 | + | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yqfF_2612282_2614417_-1 pgpH] {{PubMed|22383849}} |
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
Revision as of 13:45, 8 May 2015
- Description: c-di-AMP specific phosphodiesterase
| Gene name | pgpH |
| Synonyms | yqfF |
| Essential | no |
| Product | c-di-AMP specific phosphodiesterase |
| Function | control of c-di-AMP homeostasis |
| Gene expression levels in SubtiExpress: pgpH | |
| MW, pI | 78 kDa, 7.697 |
| Gene length, protein length | 2133 bp, 711 aa |
| Immediate neighbours | yqfG, phoH |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
metabolism of signalling nucleotides, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU25330
Phenotypes of a mutant
Database entries
- BsubCyc: BSU25330
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- hydrolysis of c-di-AMP to 5'-pApA PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Cofactors: Mn(2+) PubMed
- Effectors of protein activity:
- ppGpp acts as allosteric inhibitor of phosphodiesterase activity (in Listeria monocytogenes) PubMed
- Interactions:
- PgpH is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of interactions PubMed
- Localization:
- cell membrane PubMed (according to UniProt)
Database entries
- BsubCyc: BSU25330
- Structure:
- UniProt: P46344
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- SM-GN1 (yqfF-spc), available in Anne Galinier's and Boris Görke's labs
- BKE25330 (yqfF::erm without terminator, available in the BGSC and in Jörg Stülke's lab)
- GP2033 (yqfF::tet, available in Jörg Stülke's lab)
- GP2034 (yqfF::erm without terminator, available in Jörg Stülke's lab)
- GP2049 (yqfF::cat without terminator, available in Jörg Stülke's lab)
- Expression vector:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Fabian M Commichau, Achim Dickmanns, Jan Gundlach, Ralf Ficner, Jörg Stülke
A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP.
Mol Microbiol: 2015, 97(2);189-204
[PubMed:25869574]
[WorldCat.org]
[DOI]
(I p)
John D Helmann
Chemical proteomics reveals a second family of cyclic-di-AMP hydrolases.
Proc Natl Acad Sci U S A: 2015, 112(7);1921-2
[PubMed:25637595]
[WorldCat.org]
[DOI]
(I p)
Original publications
