cysJ

cysJ
168

sulfite reductase (NADPH2) (alpha subunit)

Locus
BSU_33440
Molecular weight
67.08 kDa
Isoelectric point
4.57
Protein length
605 aaSequenceBlast
Gene length
1818 bpSequenceBlast
Function
sulfite reduction
Product
sulfite reductase (NADPH2)
Essential
no
Synonyms
cysJ, yvgQ
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0369 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,432,339 3,434,156
Phenotypes of a mutant
unable to grow with sulfate or sulfite as the only sulfur source PubMed
defective in the the ability to support the growth of Synechococcus leopoliensis CCAP1405/1 on agar media PubMed
The protein
Catalyzed reaction/ biological activity
3 H2O + hydrogen sulfide + 3 NADP+ --> 4 H+ + 3 NADPH + sulfite (according to UniProt)
Domains
Flavodoxin-like domain (aa 68-206) (according to UniProt)
FAD-binding FR-type domain (aa 235-454) (according to UniProt)
Cofactors
FMN PubMed
FAD PubMed
Structure
5GXU (PDB) (from Arabidopsis, 32% identity)
O32214 (AlphaFold)
Additional information
belongs to the 100 most abundant proteins PubMed
Expression and Regulation
Operons
Genes
cysI-cysJ
Description
PubMed
Regulation
induced by sulfite, sulfate, and thiosulfate (CysL) PubMed
Regulatory mechanism
CysL: activation, PubMed, in cysL regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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cysI→cysJ

2025-04-03 23:03:20

ghost

101

c76dbdd9ed7d8724551be3211cb722c3be05ea7a

CF5DADBE8969C7BB4BA71235FA6595D0555E76EC

Biological materials
Mutant
1A802 ( cysJ::kan), PubMed, available at BGSC
1A934 ( cysJ::kan), PubMed, available at BGSC
BKE33440 (cysJ::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAACGTATCCACCTCACAAA, downstream forward: _UP4_TGATTTGACTTGAAAGGAGT
BKK33440 (cysJ::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CAACGTATCCACCTCACAAA, downstream forward: _UP4_TGATTTGACTTGAAAGGAGT
References
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Page visits: 3944

Time of last update: 2025-04-04 04:14:46

Author of last update: Jstuelk