Difference between revisions of "KtrA"
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[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] |
Revision as of 16:06, 17 April 2015
- Description: high affinity potassium transporter KtrA-KtrB, peripheric membrane component (proton symport)
Gene name | ktrA |
Synonyms | yuaA |
Essential | no |
Product | high affinity potassium transporter KtrA-KtrB, peripheric membrane component (proton symport) |
Function | potassium uptake |
Gene expression levels in SubtiExpress: ktrA | |
Interactions involving this protein in SubtInteract: KtrA | |
Metabolic function and regulation of this protein in SubtiPathways: Metal ion homeostasis, ktrA | |
MW, pI | 24 kDa, 5.981 |
Gene length, protein length | 666 bp, 222 aa |
Immediate neighbours | bslA, ktrB |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
transporters/ other, metal ion homeostasis (K, Na, Ca, Mg), coping with hyper-osmotic stress, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU31090
Phenotypes of a mutant
Database entries
- BsubCyc: BSU31090
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s): KtrC
Extended information on the protein
- Kinetic information:
- Domains:
- contains a RCK_N domain at the N-terminus (according to UniProt, [2])
- contains a RCK_C domain at the C-terminus (according to UniProt, [3])
- Modification:
- Effectors of protein activity:
- Localization: peripheral membrane protein PubMed
Database entries
- BsubCyc: BSU31090
- UniProt: O32080
- KEGG entry: [4]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- expression is controlled via termination antitermination by the ydaO riboswitch, expression is switched off upon binding of c-di-AMP PubMed
- Additional information:
Biological materials
- Mutant:
- 1A954 ( ktrA::kan), PubMed, available at BGSC
- GHB1 (D(ktrA-ktrB)::aphA3), available in Erhard Bremer's lab
- GP92 (D(ktrA-ktrB)::aphA3), available in Jörg Stülke's lab
- Expression vector:
- pGP2594: (IPTG inducible expression, purification in E. coli with N-terminal His-tag, in pWH844), available in Jörg Stülke's lab
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Erhard Bremer, University of Marburg, Germany homepage
Your additional remarks
References
Reviews
Fabian M Commichau, Achim Dickmanns, Jan Gundlach, Ralf Ficner, Jörg Stülke
A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP.
Mol Microbiol: 2015, 97(2);189-204
[PubMed:25869574]
[WorldCat.org]
[DOI]
(I p)
Original publications