sigF

sigF
168

RNA polymerase forespore-specific (early) sigma factor SigF

Locus
BSU_23450
Molecular weight
29.22 kDa
Isoelectric point
5.08
Protein length
255 aaSequenceBlast
Gene length
768 bpSequenceBlast
Function
transcription of sporulation genes (early forespore)
Product
RNA polymerase forespore-specific (early) sigma factor SigF
Essential
no
Synonyms
sigF, spoIIAC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1191 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,443,429 → 2,444,196
The protein
Protein family
Sigma-70 factor family (according to UniProt)
Structure
1L0O (PDB) (complex with SpoIIAB, Geobacillus stearothermophilus) PubMed
P07860 (AlphaFold)
Paralogous protein(s)
SigG
Expression and Regulation
Operons
Genes
spoIIAA-spoIIAB-sigF
Description
PubMed
Regulation
''spoIIAA'': expressed early during sporulation
Regulatory mechanism
Spo0A: activation, PubMed, in spo0A regulon
AbrB: repression, PubMed, in abrB regulon
SinR: repression, in sinR regulon
Sigma factors
SigF: sigma factor, in sigF regulon
SigG: sigma factor, in sigG regulon
SigH: sigma factor, in sigH regulon
Open in new tab

spoIIAA→sigF

2025-03-30 14:31:55

ghost

136

64b4f19f43ec57e308620c649e41be0eaadae6be

781B7F1839769E51F61804AF186C6D2AF7A0DA95

Genes
dacF-spoIIAA-spoIIAB-sigF
Description
PubMed
Regulation
''spoIIAA'': expressed early during sporulation
Regulatory mechanism
AbrB: repression, PubMed, in abrB regulon
Sigma factors
SigF: sigma factor, PubMed, in sigF regulon
SigG: sigma factor, in sigG regulon
Open in new tab

dacF→sigF

2025-03-16 16:43:36

ghost

139

3937ee398a65a809f372c4c59231b1d2e3c32629

AEBA18A2591E8C2953E0D2D62B0F6CD480E5CB2B

Biological materials
Mutant
BKE23450 (ΔsigF::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CTCCACATCCATAACAAATC,  downstream forward: _UP4_TAGTCTGCAGTGCAGGCTAG
BKK23450 (ΔsigF::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CTCCACATCCATAACAAATC,  downstream forward: _UP4_TAGTCTGCAGTGCAGGCTAG
Labs working on this gene/protein
Charles Moran, Emory University, NC, USA homepage
References
Reviews
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Original Publications
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The SigF regulon
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CFF318EE6CACDEE763FBF96A2ABB46E944679AAA

Page visits: 13833

Time of last update: 2025-04-04 02:35:57

Author of last update: Jstuelk