ung

ung
168

uracil-DNA glycosylase

Locus
BSU_37970
Molecular weight
25.90 kDa
Isoelectric point
8.78
Protein length
225 aaSequenceBlast
Gene length
678 bpSequenceBlast
Function
DNA repair
Product
uracil-DNA glycosylase
Essential
no
Synonyms
ung, ipa-57d, ywdG
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0692 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,897,685 → 3,898,362
Phenotypes of a mutant
increased mutation rates PubMed
The protein
Catalyzed reaction/ biological activity
removes uracil preferentially from single-stranded DNA over double-stranded DNA, exhibiting higher preference for U:G than U:A mismatches PubMed
Protein family
uracil-DNA glycosylase (UDG) superfamily (single member, according to UniProt)
Structure
3A7N (PDB) (from Mycobacterium tuberculosis, 42% identity) PubMed
P39615 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
ung
Description
PubMed
Regulation
expressed throughout growth and staionary phase PubMed
Open in new tab

ung

2025-03-23 18:54:06

ghost

107

fac25365a9214f8c530abd9dea93947ed89ac925

2C26D36E102505858B4708A4BC37F1769EC0CFCA

Genes
ywdF-ung
Description
PubMed
Open in new tab

ywdF→ung

2025-03-06 12:24:03

Jstuelk

79

5cf885102714c9a598bee66fc7cb76689422527d

81E81ED183B4658297E0325FE66140398B5EED5E

Biological materials
Mutant
BKE37970 (Δung::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AAGCTGTTTCAAGATTCAGG,  downstream forward: _UP4_TAAAAAGCGCAGGTGATCTG
BKK37970 (Δung::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AAGCTGTTTCAAGATTCAGG,  downstream forward: _UP4_TAAAAAGCGCAGGTGATCTG
References
Reviews
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Original Publications
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DC73C11C3C54D35B2D9A0A28666A29E36451E7F8

Page visits: 1857

Time of last update: 2025-04-20 20:44:36

Author of last update: Jstuelk