rsbW

rsbW
168

anti-sigma factor to SigB, protein serine kinase, phosphorylates RsbV

Locus
BSU_04720
Molecular weight
17.85 kDa
Isoelectric point
4.28
Protein length
160 aaSequenceBlast
Gene length
483 bpSequenceBlast
Function
control of SigB activity
Product
anti-sigma factor, protein serine kinase
Essential
no
Synonyms
rsbW
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2172 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
522,414  522,896
The protein
Catalyzed reaction/ biological activity
phosphorylation of RsbV
negative regulator (by binding) of SigB
ATP + L-seryl-[protein] --> ADP + H+ + O-phospho-L-seryl-[protein] (according to UniProt)
ATP + L-threonyl-[protein] --> ADP + H+ + O-phospho-L-threonyl-[protein] (according to UniProt)
Protein family
anti-sigma-factor family (with SpoIIAB, according to UniProt)
Structure
1TIL (PDB) (SpoIIAB, 32% identity) PubMed
P17904 (AlphaFold)
Expression and Regulation
Operons
Genes
rsbR-rsbS-rsbT-rsbU-rsbV-rsbW-sigB-rsbX
Description
PubMed
Regulation
''rsbV:'' induced by stress (SigB) PubMed
Regulatory mechanism
CcpA: repression, PubMed, in ccpA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigB: sigma factor, PubMed, in sigB regulon
Open in new tab

rsbR→rsbX

2025-04-04 06:45:52

ghost

228

5f220975cc2493224a8aa0770ee2187c815a2127

3EFC8DC1AC54632D4F2AC30497749AB5CCA3A39F

Genes
rsbV-rsbW-sigB-rsbX
Description
PubMed
Regulation
''rsbV:'' induced by stress (SigB) PubMed
Open in new tab

rsbV→rsbX

2025-03-19 09:46:09

ghost

134

c245857c04f8cca86e1f0627f3b25353c582e66e

E6CC0B507AA5819A4C5EBF800596629708A2B80D

Biological materials
Mutant
BKE04720 (rsbW::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTCGATGTAATCAGCATTAT,  downstream forward: _UP4_TATTTAAATGGGGAGCGAGT
BKK04720 (rsbW::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTCGATGTAATCAGCATTAT,  downstream forward: _UP4_TATTTAAATGGGGAGCGAGT
Labs working on this gene/protein
Bill Haldenwang, San Antonio, USA
Chet Price, Davis, USA homepage
References
Reviews
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Original Publications
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5AF5F199C5D92E13DE1C56E28948A557E3954CBF

Page visits: 5665

Time of last update: 2025-04-06 06:05:50

Author of last update: Jstuelk