atpA

atpA
168

ATP synthase, part of the F1 complex (subunit alpha)

Locus
BSU_36830
Molecular weight
54.43 kDa
Isoelectric point
5.04
Protein length
502 aaSequenceBlast
Gene length
1509 bpSequenceBlast
Function
ATP synthesis
Product
ATP synthase (subunit alpha)
Essential
no
E.C.
3.6.3.14
Synonyms
atpA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0056 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,783,878 3,785,386
The protein
Catalyzed reaction/ biological activity
ATP + 4 H+ + H2O --> ADP + 5 H+ + phosphate (according to UniProt) see a video
Protein family
ATPase alpha/beta chains family (with FliI and AtpD, according to UniProt)
Structure
1SKY (PDB) (AtpA-AtpD complex from Bacillus sp., 88% identity) PubMed
see here an overview on ATPase structure (PDB)
P37808 (AlphaFold)
Modification
phosphorylated on ser/ thr/ tyr PubMed
Effectors of protein activity
ATPase activity is inhibited upon binding of Mg-ADP to AtpD PubMed
Localization
membrane PubMed
peripheral via theF0 complex
Additional information
belongs to the 100 most abundant proteins PubMed
Expression and Regulation
Operons
Genes
atpI-atpB-atpE-atpF-atpH-atpA-atpG-atpD-atpC
Description
PubMed
Regulation
Rel dependent downregulation (Class I) during stringent response PubMed
the mRNA is processed between atpI and atpB by RNase Y, this requires the RicA-RicF-RicT complex PubMed
Regulatory mechanism
stringent response: negative regulation, in stringent response
Open in new tab

atpI→atpC

2025-03-16 15:54:05

Jstuelk

137

c30b9914547f38015d481b305686327f4f8f18d8

1C7DF7F5F812B06EFE55424A9900C106B30D346A

Biological materials
Mutant
BKE36830 (atpA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_GATGCTCACTTAGGTTTCAC, downstream forward: _UP4_TAACTCGAATGCTGATGAGA
BKK36830 (atpA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_GATGCTCACTTAGGTTTCAC, downstream forward: _UP4_TAACTCGAATGCTGATGAGA
References
Reviews
Loading
Research papers
Loading
Original Publications
Loading

E3FADE979CE6AB6315F67812608FCE00CF4E2453

Page visits: 6286

Time of last update: 2025-04-09 17:46:06

Author of last update: Jstuelk