bdbB

bdbB
168

thiol-disulfide oxidoreductase

Locus
BSU_21440
Molecular weight
17.00 kDa
Isoelectric point
9.41
Protein length
148 aaSequenceBlast
Gene length
447 bpSequenceBlast
Function
oxidative folding of proteins
Product
thiol-disulfide oxidoreductase
Essential
no
Synonyms
bdbB, yolK
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1495 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,265,225  2,265,671
The protein
Catalyzed reaction/ biological activity
oxidative folding of SunA (together with BdbC)
Protein family
DsbB family (with BdbC, according to UniProt)
Structure
P68571 (AlphaFold)
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
sunA-sunT-bdbA-sunS-bdbB
Description
PubMed
Regulation
repressed by Rok-DnaA PubMed
expression starts in the stationary phase PubMed
expression is heterogeneous in the population, this is mediated by AbrB, Rok, and Spo0A PubMed
Regulatory mechanism
Rok: repression, PubMed, in rok regulon
Abh: activation, PubMed, in abh regulon
DnaA: repression, Rok-DnaA PubMed, in dnaA regulon
YvrHb: activation, PubMed, in yvrHb regulon
AbrB: repression, PubMed, in abrB regulon
Additional information
the mRNA is very stable (> 15 min) PubMed
the amount of the mRNA is substantially decreased upon depletion of RNase Y PubMed
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sunA→bdbB

2025-04-02 04:13:45

Jstuelk

116

173a6d1c6c62ab55ab2900d516e97b549076ae97

85D1B8FA2F46C6C22D4D5CAD32F0080E33BACFA0

Biological materials
Mutant
BKE21440 (bdbB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AAATGATTTTACATATCTTG,  downstream forward: _UP4_TGAATAAGAAGTAACCCGCC
BKK21440 (bdbB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AAATGATTTTACATATCTTG,  downstream forward: _UP4_TGAATAAGAAGTAACCCGCC
References
Reviews
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Original Publications
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12CE5AE0BD02C989E803480A1CE5A47D6192D751

Page visits: 5084

Time of last update: 2025-04-05 12:25:53

Author of last update: Melvin.boenninger