ybdJ

ybdJ
168

two-component response regulator (OmpR family)

Locus
BSU_02000
Molecular weight
26.03 kDa
Isoelectric point
6.35
Protein length
223 aaSequenceBlast
Gene length
672 bpSequenceBlast
Function
unknown
Product
two-component response regulator (OmpR family)
Essential
no
Synonyms
ybdJ
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0745 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
221,258  221,929
The protein
Protein family
OmpR family of two-component response regulators
Domains
Response regulatory domain (aa 5-116) (according to UniProt)
Structure
1KGS (PDB)(from Thermotoga maritima, 32% identity) PubMed
O31432 (AlphaFold)
Modification
phosphorylated by YbdK on an Asp residue
Effectors of protein activity
phosphorylation likely affects DNA-binding activity
Localization
cytoplasm (according to Swiss-Prot)
Biological materials
Mutant
MGNA-B956 (ybdJ::erm), available at the NBRP B. subtilis, Japan
BKE02000 (ybdJ::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GATTAAAATACGATAACCCT,  downstream forward: _UP4_TGAAGCTCAAGACAAAATAT
BKK02000 (ybdJ::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GATTAAAATACGATAACCCT,  downstream forward: _UP4_TGAAGCTCAAGACAAAATAT
References
Leyn SA, Kazanov MD, Sernova NV, Ermakova EO, Novichkov PS, Rodionov DA Genomic reconstruction of the transcriptional regulatory network in Bacillus subtilis. Journal of bacteriology. 2013 Jun; 195(11):2463-73. doi:10.1128/JB.00140-13. PMID:23504016
Buckler DR, Zhou Y, Stock AM Evidence of intradomain and interdomain flexibility in an OmpR/PhoB homolog from Thermotoga maritima. Structure (London, England : 1993). 2002 Feb; 10(2):153-64. . PMID:11839301
Fabret C, Feher VA, Hoch JA Two-component signal transduction in Bacillus subtilis: how one organism sees its world. Journal of bacteriology. 1999 Apr; 181(7):1975-83. . PMID:10094672

5F6D14A0B360832F9FD470668B006A628B109A56

Page visits: 2434

Time of last update: 2025-04-06 09:29:31

Author of last update: Melvin.boenninger