sigX

sigX
168

RNA polymerase ECF-type sigma factor SigX, required for resistance against cationic antimicrobial peptides, required for temporary phage resistance

Locus
BSU_23100
Molecular weight
23.03 kDa
Isoelectric point
6.09
Protein length
194 aaSequenceBlast
Gene length
585 bpSequenceBlast
Function
resistance to cationic antimcrobial peptides
Product
RNA polymerase ECF-type sigma factor SigX
Essential
no
Synonyms
sigX, ypuM
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1595 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,414,627 → 2,415,211
The protein
Protein family
Sigma-70 factor family (according to UniProt)
ECF subfamily (according to UniProt)
Structure
6DXO (PDB) (from Streptomyces venezuelae, 28% identity) PubMed
P35165 (AlphaFold)
Localization
cell membrane (according to UniProt)
Additional information
SigX is activated in non-infected cell following phage infection of neighbor cells PubMed
Expression of the SigX regulon in increased in ''ugtP'' mutants PubMed
Expression and Regulation
Operons
Genes
sigX-rsiX
Description
PubMed
Regulation
induced by glucose PubMed, this depends on RnpM PubMed
Regulatory mechanism
YvrHb: activation, PubMed, in yvrHb regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigX: sigma factor, PubMed, in sigX regulon
Open in new tab

sigX→rsiX

2025-03-27 17:11:12

Jstuelk

116

dfd4194b5990a1043dfc2b94c54efc3adc6fd3a9

F164A2C76E6C51307B22A33B48976CF41577CBAC

Biological materials
Mutant
MGNA-A179 (sigX::erm), available at the NBRP B. subtilis, Japan
1A901 ( sigX::spec), PubMed, available at BGSC
BKE23100 (ΔsigX::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTGAAACCCCTCCGTTC,  downstream forward: _UP4_GAGCTTTTGAGGGAGGAGCT
BKK23100 (ΔsigX::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTGAAACCCCTCCGTTC,  downstream forward: _UP4_GAGCTTTTGAGGGAGGAGCT
References
Reviews
Loading
Other original publications
Loading
The SigX regulon
Loading

E77364F274A520FCCA9F5C9504E317B047BA29E6

Page visits: 7942

Time of last update: 2025-04-04 19:41:37

Author of last update: Jstuelk