essB

essB
168

membrane pseudokinase-like protein, part of the type VII protein secretion system YukD-EssB-YukB-YueB-YueC

Locus
BSU_31890
Molecular weight
52.00 kDa
Isoelectric point
4.68
Protein length
451 aaSequenceBlast
Gene length
1356 bpSequenceBlast
Function
export of YfjA, YukE, YxiB, YwqH
Product
membrane pseudokinase-like protein, part of the type VII protein secretion system
Essential
no
Synonyms
yukC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4499 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,274,462  3,275,817
Phenotypes of a mutant
loss of secretion of YukE PubMed
The protein
Catalyzed reaction/ biological activity
export of YfjA, YukE, YxiB, YwqH PubMed
secretion and delivery of LXG domain toxins PubMed
Protein family
EssB family (single member, according to UniProt)
Domains
N-terminal pseudokinase domain (aa 3 - 206) PubMed
transmembrane domain (aa 220 - 243) PubMed
C-terminal extracellular domain (aa 244 - 384) PubMed
Structure
6Z0F (PDB) PubMed
4ANO (PDB) (from Geobacillus thermodenitrificans, corresponds to the cytoplasmic part, aa 2 ... 218, 44% identity) PubMed
2YNQ (PDB) (from Geobacillus thermodenitrificans, corresponds to the extracellular part, aa 243 ... 384, 40% identity) PubMed
P71070 (AlphaFold)
Localization
cell membrane (according to UniProt) PubMed
Expression and Regulation
Operons
Genes
yukE-yukD-essB-yukB-yueB-yueC-yueD
Description
PubMed
Regulation
expressed in the stationary phase PubMed
expression is reduced in motile cells as compared to non-motile cells PubMed
Regulatory mechanism
DegU: activation, DegU-P, PubMed, in degU regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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yukE→yueD

2025-04-06 06:18:45

Jstuelk

133

BB0E1B9684F16E121BAA022EF986B0285FB41FA7

CDC40F8A7006CF56CF9A6155897E8BD27FFEC7AA

Biological materials
Mutant
MGNA-A626 (yukC::erm), available at the NBRP B. subtilis, Japan
BKE31890 (essB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ACCTGACATTCAACCAGATC,  downstream forward: _UP4_TAACGTGAGACATGAAGCGC
BKK31890 (essB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ACCTGACATTCAACCAGATC,  downstream forward: _UP4_TAACGTGAGACATGAAGCGC
References
Reviews
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Original Publications
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3FE4A91C7D0B43C8704391F2F9493852B3AED9B0

Page visits: 3067

Time of last update: 2025-04-10 02:45:04

Author of last update: Jstuelk