lutC

lutC
168

lactate catabolic enzyme

Locus
BSU_34030
Molecular weight
26.13 kDa
Isoelectric point
5.16
Protein length
240 aaSequenceBlast
Gene length
723 bpSequenceBlast
Function
utilization of lactate
Product
unknown
Essential
no
E.C.
null
Synonyms
lutC, yvbY
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1556 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,492,797  3,493,519
Phenotypes of a mutant
no growth with lactate as the single carbon source PubMed
The protein
Catalyzed reaction/ biological activity
oxidation of lactate to pyruvate PubMed
Protein family
LutC/YkgG family (single member, according to UniProt)
Structure
O32259 (AlphaFold)
Modification
phosphorylated on Arg-97 PubMed
Expression and Regulation
Operons
Genes
lutA-lutB-lutC
Description
PubMed
Regulation
induction by lactate PubMed
Regulatory mechanism
SinR: repression, PubMed, in sinR regulon
LutR: repression, in lutR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

lutA→lutC

2025-03-15 03:34:41

ghost

92

7db2bc789fad5a99442f7b9ff99a43f2b42b4a12

59CEB598935063C72EA3D1BE77C54FD6CCE3442E

Other regulations
FsrA: translation repression, PubMed
FbpB: translation inhibition, acts as RNA chaperone, increases interaction between FsrA and LutA-LutB-LutC RNAs
Biological materials
Mutant
MGNA-A470 (yvbY::erm), available at the NBRP B. subtilis, Japan
BKE34030 (lutC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ATTCTGAATGGTTCCCTTCG,  downstream forward: _UP4_TGAACTCAGGAAGCCCGGCA
BKK34030 (lutC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ATTCTGAATGGTTCCCTTCG,  downstream forward: _UP4_TGAACTCAGGAAGCCCGGCA
Labs working on this gene/protein
Richard Losick, Harvard Univ., Cambridge, USA homepage
References
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5EE69198882DF4E9AB8D9D7267F071EF88C2F16D

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Time of last update: 2025-04-01 00:58:26

Author of last update: Jstuelk