frlP

frlP
168

aminosugar ABC transporter (ATP-binding protein)

Locus
BSU_32550
Molecular weight
41.19 kDa
Isoelectric point
6.07
Protein length
367 aaSequenceBlast
Gene length
1104 bpSequenceBlast
Function
uptake of sugar amines
Product
aminosugar ABC transporter (ATP-binding protein)
Essential
no
Synonyms
yurJ
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3839 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,345,013  3,346,116
The protein
Protein family
ABC transporter superfamily (according to UniProt)
Domains
ABC transporter domain (aa 4-234) (according to UniProt)
Structure
1G29 (PDB) (from Thermococcus litoralis, 50% identity) PubMed
O32151 (AlphaFold)
Modification
phosphorylated on Ser-3 PubMed
Paralogous protein(s)
MsmX
Localization
membrane associated (via FrlM-FrlN) PubMed
Expression and Regulation
Operons
Genes
frlP
Description
PubMed
Regulatory mechanism
CodY: repression, PubMed, in codY regulon
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frlP

2025-03-15 05:11:40

Bzhu

68

863a1210815889f9521f7f70cfae7cff1dbe1a16

20D3A3648F7D978B9AD78A7650D9898EC704582B

Genes
frlB-frlO-frlN-frlM-frlD-frlP
Description
PubMed
Regulation
'' FrlB'': repressed during growth in the presence of branched chain amino acids (CodY) PubMed
induced in the absence of RnpM PubMed
Regulatory mechanism
CodY: repression, PubMed, PubMed, in codY regulon
FrlR: repression, PubMed, in frlR regulon
RnpM: unknown, PubMed, in rnpM regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Additional information
the frlB-frlO-frlN-frlM-frlD-frlP operon is strongly downregulated in a cshA mutant PubMed
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frlB→frlP

2025-04-04 07:33:27

Jstuelk

129

1386d0b18bc93ba0b08e1c36531a0379aa199ac3

218EAE44649CE3CDE2633AF97E4CC56ABC5AA2E3

Biological materials
Mutant
MGNA-A556 (yurJ::erm), available at the NBRP B. subtilis, Japan
BKE32550 (frlP::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCAGAAAAGTCCCCCTAT,  downstream forward: _UP4_TAGAAAAAGGTGCTCCTCAA
BKK32550 (frlP::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCAGAAAAGTCCCCCTAT,  downstream forward: _UP4_TAGAAAAAGGTGCTCCTCAA
References
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3B9331D6755B8253944AB33521BBF2B3EBA4CAEB

Page visits: 6170

Time of last update: 2025-04-04 06:15:23

Author of last update: Jstuelk