yhfR
168

phosphatase involved in isopentenol (isoprenoid) biosynthesis

Locus

BSU_10340

Molecular weight

21.85 kDa

Isoelectric point

5.16

Protein length

193 aaSequenceBlast

Gene length

582 bpSequenceBlast

Function

isoprenoid biosynthesis

Product

unknown

Essential

Synonyms

yhfR

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0406 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

1,108,736 1,109,317

Phenotypes of a mutant

no detectable phenotype PubMed

The protein

Catalyzed reaction/ biological activity

phosphatase involved in isopentenol (isoprenoid) biosynthesis

Protein family

similar to 2,3-diphosphoglycerate-dependent phosphoglycerate mutases PubMed

Structure

1H2F (PDB) (enzyme of B. stearothermophilus) PubMed

O07617 (AlphaFold)

Additional information

The gene is annotated in KEGG as an ortholog of phosphoglycerate mutase (PGM) EC 5.4.2.1. In MetaCyc the protein is marked as similar to phosphoglycerate mutase. No EC annotation is available in Swiss-Prot. Pearson et al. (PubMed) demonstrated that yhfR is non-essential for growth, sporulation, and spore germination. They also purified the gene, expressed it in B. subtilis but were not able to detect PGM activity in B. subtilis. PubMed

Expression and Regulation

Operons

Genes

yhfR

Description

PubMed

Regulatory mechanism

BirA: repression, in birA regulon

Additional information

weakly expressed PubMed

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Genes