tsaB

tsaB
168

required for threonyl carbamoyl adenosine (t6A) modification of tRNAs that pair with ANN codons in mRNA

Locus
BSU_05920
Molecular weight
25.10 kDa
Isoelectric point
5.76
Protein length
229 aaSequenceBlast
Gene length
690 bpSequenceBlast
Function
tRNA modification
Product
tRNA modification enzyme
Essential
yes
Synonyms
tsaB, ydiC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1214 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
642,111  642,800
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
biosynthesis of the threonylcarbamoyladenosine (t6A) residue at position 37 of ANN-decoding tRNAs using L-threonylcarbamoyl-AMP (TsaB-TsaD-TsaE) PubMed
Protein family
KAE1 / TsaD family (with TsaD, according to UniProt)
Structure
2A6A (PDB) (from Thermotoga maritima, 24% identity) PubMed
O05516 (AlphaFold)
Localization
cytoplasm (according to UniProt)
Expression and Regulation
Operons
Genes
thiL-tsaE-tsaB-rimI-tsaD
Description
PubMed
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thiL→tsaD

2025-03-29 12:30:01

ghost

126

45839886739c513a86015eb2db5091e043ecd558

F160E3DB3BAB4687DBF8F609242CE813EE9E1BF6

References
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6CB350C335603D5F4434679F9D740BFECA738599

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Time of last update: 2025-04-09 22:08:15

Author of last update: Jstuelk