spbK

spbK
168

NADase, protection of populations of ICEBs1 host cells from predation by the lysogenic phage SPβ

Locus
BSU_05000
Molecular weight
31.14 kDa
Isoelectric point
5.18
Protein length
266 aaSequenceBlast
Gene length
801 bpSequenceBlast
Function
protection of populations of ICEBs1 host cells from predation by the lysogenic phage SPβ
Product
NADase, TIR (Toll-interleukin-1 receptor)-domain protein
Essential
no
E.C.
null
Synonyms
yddK
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms

Gene
Coordinates
546,166  546,966
The protein
Catalyzed reaction/ biological activity
NAD+ + H2O --> ADP-D-ribose + nicotinamide + H+ PubMed
protection of populations of ICEBs1 host cells from predation by the lysogenic phage SPβ PubMed
upon induction of prophage SPß or infection with SPß, SpbK forms an abortive infection system with YonE of phage SPβ, resulting in cell death PubMed
Domains
aa 1 ... 94: N-terminal domain PubMed
aa 95 ... 114: linker domain PubMed
aa 115 ... 267: toll-interleukin-1 receptor-like (TIR) domain PubMed
Structure
P96648 (AlphaFold)
Effectors of protein activity
NADase activity is stimulated upon interaction with YonE PubMed
Expression and Regulation
Operons
Genes
spbK
Description
PubMed
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spbK

2025-03-16 01:32:24

Jstuelk

66

b2ca2308c674221392ef9522dc01665f941c1cb0

4611CCF960EE390C22A14B0474D9D222097BDD17

Biological materials
Mutant
BKE05000 (spbK::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTAGATTTCCTCCGACCT,  downstream forward: _UP4_TAACTTAAATGCCACTGCTA
BKK05000 (spbK::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTAGATTTCCTCCGACCT,  downstream forward: _UP4_TAACTTAAATGCCACTGCTA
References
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Page visits: 2627

Time of last update: 2025-04-09 18:23:58

Author of last update: Jstuelk