grpE

grpE
168

heat-shock protein (activation of DnaK)

Locus
BSU_25480
Molecular weight
21.54 kDa
Isoelectric point
4.26
Protein length
187 aaSequenceBlast
Gene length
564 bpSequenceBlast
Function
control of DnaK activity
Product
heat-shock protein
Essential
no
Synonyms
grpE
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0576 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,627,971 → 2,628,534
The protein
Protein family
grpE family (single member, according to UniProt)
Structure
4ANI (PDB) (DnaK-GrpE complex from Geobacillus kaustophilus, 70% identity) PubMed
P15874 (AlphaFold)
Localization
Cytoplasm (Homogeneous) PubMed
Expression and Regulation
Operons
Genes
hrcA-grpE-dnaK-dnaJ-yqeT-yqeU-yqeV
Description
PubMed
Regulation
induced by heat shock (HrcA) PubMed
Regulatory mechanism
HrcA: repression, PubMed, in hrcA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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hrcA→yqeV

2025-04-11 08:16:44

ghost

166

5537cbdd2a5f5134768e8ba4f02922d86d6e912b

1FEFD4DF6108A61DA84FEA3CD39009FF4CA3EC3B

Biological materials
Mutant
BKE25480 (ΔgrpE::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTGTGTTCACCTCCCTCA,  downstream forward: _UP4_TAATTACATAGCAGGAGGTT
BKK25480 (ΔgrpE::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTGTGTTCACCTCCCTCA,  downstream forward: _UP4_TAATTACATAGCAGGAGGTT
Labs working on this gene/protein
Wolfgang Schumann, Bayreuth University, Germany Homepage
References
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ECAB685E9038DC03FA2CC659112BB07D30DE5C8C

Page visits: 6060

Time of last update: 2025-04-15 21:31:58

Author of last update: Jstuelk