yabN

yabN
168

similar to nucleoside triphosphate pyrophosphohydrolase

Locus
BSU_00580
Molecular weight
55.94 kDa
Isoelectric point
4.51
Protein length
489 aaSequenceBlast
Gene length
1470 bpSequenceBlast
Function
unknown
Product
unknown
Essential
no
Synonyms
yabN
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3956 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
66,405  67,874
The protein
Domains
contains a domain similar to  E. coli mazG (nucleoside pyrophosphohydrolase) at the C-terminus (aa 240-480)
Structure
3CRA (PDB) (E. coli MazG, corresponds to the C-terminal domain, aa 238 ... 486), 43.6% identity PubMed
P37556 (AlphaFold)
Expression and Regulation
Operons
Genes
yabM-yabN-rqcP-yabP-shfA-divIC-yabR
Description
PubMed
Regulation
expressed during sporulation (SigE) PubMed
Sigma factors
SigM: sigma factor, PubMed, in sigM regulon
SigE: sigma factor, PubMed, in sigE regulon
SigW: sigma factor, PubMed, in sigW regulon
SigD: sigma factor, PubMed, in sigD regulon
SigX: sigma factor, PubMed, in sigX regulon
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yabM→yabR

2025-04-02 03:12:55

Jstuelk

118

93952be38722510f984794e138450cd80a9f7d48

0CF3909333400A3BFE18E32016883124FFC3D75B

Biological materials
Mutant
MGNA-B915 (yabN::erm), available at the NBRP B. subtilis, Japan
BKE00580 (yabN::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GGCACCAAGTCCGACGACTG,  downstream forward: _UP4_GAAACTGAGAGGAGATCATA
BKK00580 (yabN::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GGCACCAAGTCCGACGACTG,  downstream forward: _UP4_GAAACTGAGAGGAGATCATA
References
Arrieta-Ortiz ML, Hafemeister C, Bate AR, Chu T, Greenfield A, Shuster B, Barry SN, Gallitto M, Liu B, Kacmarczyk T, Santoriello F, Chen J, Rodrigues CD, Sato T, Rudner DZ, Driks A, Bonneau R, Eichenberger P An experimentally supported model of the Bacillus subtilis global transcriptional regulatory network. Molecular systems biology. 2015 Nov 17; 11(11):839. doi:10.15252/msb.20156236. PMID:26577401
Lee S, Kim MH, Kang BS, Kim JS, Kim GH, Kim YG, Kim KJ Crystal structure of Escherichia coli MazG, the regulator of nutritional stress response. The Journal of biological chemistry. 2008 May 30; 283(22):15232-40. doi:10.1074/jbc.M800479200. PMID:18353782
Asai K, Takamatsu H, Iwano M, Kodama T, Watabe K, Ogasawara N The Bacillus subtilis yabQ gene is essential for formation of the spore cortex. Microbiology (Reading, England). 2001 Apr; 147(Pt 4):919-27. . PMID:11283287

52D48F22CB53421EE30970D34B4861E2F8A5893D

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Time of last update: 2025-04-10 12:05:55

Author of last update: Jstuelk