hemC

hemC
168

hydroxymethylbilane synthase

Locus
BSU_28150
Molecular weight
34.68 kDa
Isoelectric point
5.09
Protein length
314 aaSequenceBlast
Gene length
945 bpSequenceBlast
Function
heme biosynthesis
Product
hydroxymethylbilane synthase
Essential
no
E.C.
2.5.1.61
Synonyms
hemC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms, belongs to COG0181 (Galperin et al., 2021)

This gene is a member of the following regulons

SigA regulon, PerR regulon

Gene
Coordinates
2,875,951 → 2,876,895
The protein
Catalyzed reaction/ biological activity
H2O + 4 porphobilinogen --> hydroxymethylbilane + 4 NH4+ (according to UniProt)
Protein family
HMBS family (single member, according to UniProt)
Structure
4MLQ (PDB) (from Bacillus megaterium, 70% identity) PubMed
P16616 (AlphaFold)
Expression and Regulation
Operons
Genes
hemA-hemX-hemC-hemD-hemB-hemL
Description
PubMed
Regulation
induced by hydrogen peroxide (PerR) PubMed
Regulatory mechanism
PerR: repression, PubMed, in perR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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hemA→hemL

2025-03-29 16:29:02

ghost

108

64840dd729762069005c4bd541ed0ddec6e74ace

168BC8B91CBFE3EA050DA8A9187C8C67D6BBE4F9

Biological materials
Mutant
BKE28150 (ΔhemC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCTTTCCTCCCGAATC,  downstream forward: _UP4_CGTGTAAAACGGGAGCTTGA
BKK28150 (ΔhemC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCTTTCCTCCCGAATC,  downstream forward: _UP4_CGTGTAAAACGGGAGCTTGA
References
Reviews
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Original Publications
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D266E22E07B849E2AEB0EF232C49A2FE1EA4E02B

Page visits: 2516

Time of last update: 2025-04-16 05:27:58

Author of last update: Melvin.boenninger