CssR

• Description: two-component response regulator, control of cellular responses to protein secretion stress
  
  

Gene name	cssR
Synonyms	yvqA
Essential	no
Product	two-component response regulator
Function	control of cellular responses to protein secretion stress
Gene expression levels in SubtiExpress: cssR
Interactions involving this protein in SubtInteract: CssR
Metabolic function and regulation of this protein in SubtiPathways: cssR
MW, pI	26 kDa, 5.071
Gene length, protein length	675 bp, 225 aa
Immediate neighbours	htrB, cssS
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, heat shock proteins, phosphoproteins

This gene is a member of the following regulons

CssR regulon

The CssR regulon:

• cssR-cssS, htrA, htrB

The gene

Basic information

• Locus tag: BSU33010

Database entries

• BsubCyc: BSU33010

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: OmpR family of two-component response regulators

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated by CssS on an Asp residue

• Cofactor(s):

• Effectors of protein activity: phosphorylation likely affects DNA-binding activity

• Interactions:
  • CssR interacts with the RNA polymerase PubMed
  • CssS-CssR

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• BsubCyc: BSU33010

• Structure:

• UniProt: O32192

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: cssR-cssS PubMed

• Expression browser: cssR PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • expressed under conditions of secretion stress (CssR) PubMed

• Regulatory mechanism:
  • CssR: transcription activation PubMed

• Additional information:
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 87 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: