ntdA

ntdA
168

pyridoxal phosphate-dependent 3-oxo-glucose-6-phosphate:glutamate aminotransferase

Locus
BSU_10550
Molecular weight
49.98 kDa
Isoelectric point
5.97
Protein length
441 aaSequenceBlast
Gene length
1326 bpSequenceBlast
Function
synthesis of the antibiotic kanosamine
Product
pyridoxal phosphate-dependent
Essential
no
Synonyms
ntdA, yhjL
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0399 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,128,286  1,129,611
The protein
Catalyzed reaction/ biological activity
3-oxo-d-glucose-6-phosphate + glutamate --> kanosamine-6-phosphate PubMed
Protein family
DegT/DnrJ/EryC1 family (with EpsN and SpsC, according to UniProt)
Cofactors
pyridoxalphosphate PubMed
Structure
4K2I (PDB) PubMed
O07566 (AlphaFold)
Expression and Regulation
Operons
Genes
ntdA-ntdB-ntdC-glcP
Description
PubMed
Regulation
induced by 3,3'-neotrehalosadiamine and kanosamine (NtdR) PubMed
Regulatory mechanism
NtdR: activation , in ntdR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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ntdA→glcP

2025-03-16 05:33:23

Jstuelk

109

41B772604ED3B8BA7F5F0AFF19B989A8E4F9FDC1

2A657E0F29C43EAF1C8F99F810D2B0756ABA88B3

Biological materials
Mutant
MGNA-A725 (yhjL::erm), available at the NBRP B. subtilis, Japan
BKE10550 (ntdA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGAACAGTACCTCCAATG,  downstream forward: _UP4_TTTCATGTTATTAAGCAAGA
BKK10550 (ntdA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGAACAGTACCTCCAATG,  downstream forward: _UP4_TTTCATGTTATTAAGCAAGA
References
Reviews
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Original Publications
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2F850E2DFA6287DB3890243803E06FDE7ACDB10E

Page visits: 3434

Time of last update: 2025-04-06 01:59:56

Author of last update: Jstuelk