Difference between revisions of "CymR"
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU27520 cymR] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU27520 cymR] | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=CymR CymR] |
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/ | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=cymR cymR]''' |
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 11 kDa, 9.879 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 11 kDa, 9.879 | ||
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU27520&redirect=T BSU27520] | ||
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/cymR-yrvO-trmU.html] | * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/cymR-yrvO-trmU.html] | ||
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU27520&redirect=T BSU27520] | ||
* '''Structure:''' [http://www.pdb.org/pdb/search/structidSearch.do?structureId=2Y75 2Y75] {{PubMed|21624051}} | * '''Structure:''' [http://www.pdb.org/pdb/search/structidSearch.do?structureId=2Y75 2Y75] {{PubMed|21624051}} | ||
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* '''Additional information:''' | * '''Additional information:''' | ||
| + | ** number of protein molecules per cell (minimal medium with glucose and ammonium): 508 {{PubMed|24696501}} | ||
| + | ** number of protein molecules per cell (complex medium with amino acids, without glucose): 1039 {{PubMed|24696501}} | ||
=Biological materials = | =Biological materials = | ||
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<pubmed>16513748, </pubmed> | <pubmed>16513748, </pubmed> | ||
==Other original publications== | ==Other original publications== | ||
| − | + | <pubmed>18974048,17056751,16109943,16885442 11948165 , 15668000 20608979 21624051</pubmed> | |
| − | <pubmed>18974048,17056751,16109943,16885442 11948165 , 15668000 20608979</pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Latest revision as of 09:35, 17 April 2014
- Description: pleiotropic regulator of sulfur metabolism
| Gene name | cymR |
| Synonyms | yrzC |
| Essential | no |
| Product | transcription repressor |
| Function | regulation of sulfur metabolism |
| Gene expression levels in SubtiExpress: cymR | |
| Interactions involving this protein in SubtInteract: CymR | |
| Metabolic function and regulation of this protein in SubtiPathways: cymR | |
| MW, pI | 11 kDa, 9.879 |
| Gene length, protein length | 333 bp, 111 aa |
| Immediate neighbours | yrvO, yrvN |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
sulfur metabolism, transcription factors and their control, regulators of core metabolism
This gene is a member of the following regulons
The CymR regulon
The gene
Basic information
- Locus tag: BSU27520
Phenotypes of a mutant
- impaired growth in the presence of cystine and increased sensitivity to hydrogen peroxide-, disulfide-, paraquat- and tellurite-induced stresses PubMed
- increased intracellular cysteine pool and hydrogen sulfide formation PubMed
- depletion of branched-chain amino acids PubMed
Database entries
- BsubCyc: BSU27520
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: Rrf2 family of transcription regulators
- Paralogous protein(s):
Genes repressed by CymR
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- BsubCyc: BSU27520
- UniProt: O34527
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Isabelle Martin-Verstraete, Institute Pasteur, Paris, France
Your additional remarks
References
The CymR regulon
Sergine Even, Pierre Burguière, Sandrine Auger, Olga Soutourina, Antoine Danchin, Isabelle Martin-Verstraete
Global control of cysteine metabolism by CymR in Bacillus subtilis.
J Bacteriol: 2006, 188(6);2184-97
[PubMed:16513748]
[WorldCat.org]
[DOI]
(P p)
Other original publications
