dra

dra
168

deoxyribose-phosphate aldolase

Locus
BSU_39420
Molecular weight
22.06 kDa
Isoelectric point
4.93
Protein length
223 aaSequenceBlast
Gene length
672 bpSequenceBlast
Function
utilization of nucleotides as carbon source
Product
deoxyribose-phosphate aldolase
Essential
no
E.C.
4.1.2.4
Synonyms
dra, deoC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms, belongs to COG0274 (Galperin et al., 2021)

This gene is a member of the following regulons

SigA regulon, CcpA regulon, DeoR regulon

Gene
Coordinates
4,051,602  4,052,273
The protein
Catalyzed reaction/ biological activity
2-deoxy-D-ribose 5-phosphate --> acetaldehyde + D-glyceraldehyde 3-phosphate (according to UniProt)
Protein family
DeoC/FbaB aldolase family (single member, according to UniProt)
Structure
1MZH (PDB) (from Aquifex aeolicus, 42% identity, 62% similarity)
P39121 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
dra-nupC-pdp
Description
PubMed
Regulation
induced by deoxynucleotides (DeoR) PubMed
Regulatory mechanism
CcpA: repression, PubMed, in ccpA regulon
DeoR: repression, PubMed, in deoR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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dra→pdp

2025-04-02 10:15:47

ghost

91

b24eb750b98d8d0cd62de8826e0fdd903ded3523

FF2BA988E6DC720FC1826E0AE14DD57A6A640267

Biological materials
Mutant
BKE39420 (dra::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCCTTCGCACACTTCCTT,  downstream forward: _UP4_TAAGAGCTGACGGAAGGCAG
BKK39420 (dra::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCCTTCGCACACTTCCTT,  downstream forward: _UP4_TAAGAGCTGACGGAAGGCAG
References
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Page visits: 3984

Time of last update: 2025-04-05 16:34:20

Author of last update: Melvin.boenninger