SpoVC

• Description: general stress protein, peptidyl-tRNA hydrolase
  
  

Gene name	spoVC
Synonyms	pth
Essential	yes PubMed
Product	peptidyl-tRNA hydrolase
Function	spore coat formation
Gene expression levels in SubtiExpress: spoVC
MW, pI	20 kDa, 5.58
Gene length, protein length	564 bp, 188 aa
Immediate neighbours	ctc, fin
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

translation, general stress proteins (controlled by SigB), essential genes sporulation proteins

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

• Locus tag: BSU00530

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU00530

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: N-substituted aminoacyl-tRNA + H₂O = N-substituted amino acid + tRNA (according to Swiss-Prot)

• Protein family: PTH family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• BsubCyc: BSU00530

• Structure:

• UniProt: P37470

• KEGG entry: [2]

• E.C. number: 3.1.1.29

Expression and regulation

• Operon:

• Expression browser: spoVC PubMed

• Sigma factor: SigB PubMed

• Regulation: induced by stress (SigB) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Jeanne Menez, Richard H Buckingham, Miklos de Zamaroczy, Celine Karmazyn Campelli
Peptidyl-tRNA hydrolase in Bacillus subtilis, encoded by spoVC, is essential to vegetative growth, whereas the homologous enzyme in Saccharomyces cerevisiae is dispensable.
Mol Microbiol: 2002, 45(1);123-9
[PubMed:12100553] [WorldCat.org] [DOI] (P p)

A Petersohn, M Brigulla, S Haas, J D Hoheisel, U Völker, M Hecker
Global analysis of the general stress response of Bacillus subtilis.
J Bacteriol: 2001, 183(19);5617-31
[PubMed:11544224] [WorldCat.org] [DOI] (P p)