mrpD

mrpD
168

H+ transporter subunit of the Na+/H+ antiporter, multiple resistance and pH homeostasis

Locus
BSU_31630
Molecular weight
53.21 kDa
Isoelectric point
9.49
Protein length
493 aaSequenceBlast
Gene length
1482 bpSequenceBlast
Function
sodium export
Product
Na+/H+ antiporter subunit
Essential
yes
Synonyms
mrpD, yufD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0651 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,249,761  3,251,242
Phenotypes of a mutant
essential PubMed
a ''mrpD'' mutant is viable at pH7.4 and sodium concentrations below 80 mM PubMed
The protein
Catalyzed reaction/ biological activity
H+ transporter subunit of the Na+/H+ antiporter PubMed
Protein family
CPA3 antiporters (TC 2.A.63) subunit D family (single member, according to UniProt)
Structure
4HE8 (PDB) (from Thermus thermophilus, 26% identity) PubMed
O05229 (AlphaFold)
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
mrpA-mrpB-mrpC-mrpD-mrpE-mrpF-mrpG
Description
PubMed
Open in new tab

mrpA→mrpG

2025-03-10 23:20:34

ghost

93

0833d14430981483bcfaa13a7a8e288e077b523f

4FC54E916920821D8932F58F7DE85186D61907A1

Biological materials
Mutant
MGNA-A609 (yufD::erm), available at the NBRP B. subtilis, Japan
References
Reviews
Loading
Original Publications
Loading

051D9BCC0CB05E39ED5825BB9BA77B8228EA055D

Page visits: 3102

Time of last update: 2025-04-10 13:47:37

Author of last update: Jstuelk