mrpA

mrpA
168

Na+ transporter subunit of the Na+/H+ antiporter, multiple resistance and pH homeostasis

Locus
BSU_31600
Molecular weight
86.23 kDa
Isoelectric point
9.52
Protein length
774 aaSequenceBlast
Gene length
2325 bpSequenceBlast
Function
sodium export
Product
Na+/H+ antiporter subunit
Essential
yes
Synonyms
mrpA, yufT, shaA, ntrA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2111 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,246,679 → 3,249,003
Phenotypes of a mutant
essential PubMed
a ''mrpA'' mutant is viable at pH7.4 and sodium concentrations below 80 mM PubMed
the ''mrpA'' mutant accumulates internal sodium PubMed
The protein
Catalyzed reaction/ biological activity
Na  transporter subunit of the Na /H  antiporter PubMed
Protein family
CPA3 antiporters (TC 2.A.63) subunit A family (single member, according to UniProt)
Structure
4HE8 (PDB) (from Thermus thermophilus, 36% identity in a 57% fragment) PubMed
Q9K2S2 (AlphaFold)
Localization
inner spore membrane PubMed
Expression and Regulation
Operons
Genes
mrpA-mrpB-mrpC-mrpD-mrpE-mrpF-mrpG
Description
PubMed
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mrpA→mrpG

2025-03-10 23:20:34

ghost

93

0833d14430981483bcfaa13a7a8e288e077b523f

4FC54E916920821D8932F58F7DE85186D61907A1

Biological materials
Mutant
MGNA-B557 (yufT::erm), available at the NBRP B. subtilis, Japan
References
Reviews
Ito M, Morino M, Krulwich TA Mrp Antiporters Have Important Roles in Diverse Bacteria and Archaea. Frontiers in microbiology. 2017; 8:2325. doi:10.3389/fmicb.2017.02325. PMID:29218041
Original Publications
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Time of last update: 2025-04-09 16:12:40

Author of last update: Jstuelk