HemZ

• Description: coproporphyrinogen III oxidase
  
  

Gene name	hemZ
Synonyms	yhaW, yhaV
Essential	no
Product	coproporphyrinogen III oxidase
Function	heme biosynthesis
Gene expression levels in SubtiExpress: hemZ
Metabolic function and regulation of this protein in SubtiPathways: HemZ
MW, pI	57 kDa, 5.899
Gene length, protein length	1503 bp, 501 aa
Immediate neighbours	yhaX, khtU
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

Rex regulon

The gene

Basic information

• Locus tag: BSU09840

Database entries

• BsubCyc: BSU09840

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Coproporphyrinogen-III + 2 S-adenosyl-L-methionine = protoporphyrinogen-IX + 2 CO₂ + 2 L-methionine + 2 5'-deoxyadenosine (according to Swiss-Prot)

• Protein family: anaerobic coproporphyrinogen III oxidase family (according to Swiss-Prot)

• Paralogous protein(s): hemN

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU09840

• Structure:

• UniProt: Q796V8

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: hemZ PubMed

• Expression browser: hemZ PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced under anaerobic conditions during growth in the presence of nitrate (no induction in the absence of terminal electron acceptor) (Fnr, ResD, ArfM) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

G Homuth, A Rompf, W Schumann, D Jahn
Transcriptional control of Bacillus subtilis hemN and hemZ.
J Bacteriol: 1999, 181(19);5922-9
[PubMed:10498703] [WorldCat.org] [DOI] (P p)