Difference between revisions of "EfeU"
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− | * '''Description:''' elemental iron uptake system (permease) <br/><br/> | + | * '''Description:''' elemental iron uptake system (permease), high affinity uptake of ferric iron (Fe(III)) <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Product''' || elemental iron uptake system (permease) | |style="background:#ABCDEF;" align="center"| '''Product''' || elemental iron uptake system (permease) | ||
|- | |- | ||
− | |style="background:#ABCDEF;" align="center"|'''Function''' || iron uptake | + | |style="background:#ABCDEF;" align="center"|'''Function''' || elemental iron uptake |
+ | |- | ||
+ | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU38280 efeU] | ||
+ | |- | ||
+ | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/EfeU EfeU] | ||
+ | |- | ||
+ | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=EfeU EfeU]''' | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 52 kDa, 8.958 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 52 kDa, 8.958 | ||
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|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1443 bp, 481 aa | |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1443 bp, 481 aa | ||
|- | |- | ||
− | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ | + | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[efeO]]'', ''[[thiE]]'' |
|- | |- | ||
− | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU38280 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU38280 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU38280 DNA_with_flanks] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:ywbL_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:ywbL_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
+ | |- | ||
+ | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=efeU_3929105_3930550_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:ywbL_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU38280]] | ||
|- | |- | ||
|} | |} | ||
__TOC__ | __TOC__ | ||
+ | <br/><br/><br/><br/> | ||
+ | <br/><br/><br/><br/> | ||
+ | <br/><br/><br/><br/> | ||
+ | <br/><br/> | ||
+ | |||
+ | = [[Categories]] containing this gene/protein = | ||
+ | {{SubtiWiki category|[[transporters/ other]]}}, | ||
+ | {{SubtiWiki category|[[acquisition of iron]]}}, | ||
+ | {{SubtiWiki category|[[iron metabolism]]}}, | ||
+ | {{SubtiWiki category|[[membrane proteins]]}} | ||
− | + | = This gene is a member of the following [[regulons]] = | |
+ | {{SubtiWiki regulon|[[Fur regulon]]}} | ||
=The gene= | =The gene= | ||
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=== Basic information === | === Basic information === | ||
− | * ''' | + | * '''Locus tag:''' BSU38280 |
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
Line 46: | Line 65: | ||
=== Additional information=== | === Additional information=== | ||
+ | |||
+ | |||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
− | * '''Interactions:''' | + | * '''[[SubtInteract|Interactions]]:''' |
+ | ** [[EfeO]]-[[EfeU]]-[[EfeB]] {{PubMed|23180473,23764491}} | ||
− | * '''Localization:''' cell membrane (according to Swiss-Prot) | + | * '''[[Localization]]:''' |
+ | ** cell membrane (according to Swiss-Prot) | ||
=== Database entries === | === Database entries === | ||
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* '''Structure:''' | * '''Structure:''' | ||
− | * ''' | + | * '''UniProt:''' [http://www.uniprot.org/uniprot/P39595 P39595] |
− | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu | + | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU38280] |
* '''E.C. number:''' | * '''E.C. number:''' | ||
Line 87: | Line 110: | ||
=Expression and regulation= | =Expression and regulation= | ||
+ | * '''Operon:''' | ||
+ | ** ''[[efeU]]-[[efeO]]-[[efeB]]'' {{PubMed|9353933}} | ||
− | * ''' | + | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=efeU_3929105_3930550_-1 efeU] {{PubMed|22383849}} |
− | * ''' | + | * '''Sigma factor:''' [[SigA]] {{PubMed|23764491}} |
* '''Regulation:''' | * '''Regulation:''' | ||
+ | ** induced upon iron starvation ([[Fur]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed] | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
+ | ** [[Fur]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12354229 PubMed] | ||
− | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Line 118: | Line 145: | ||
=References= | =References= | ||
− | + | <pubmed>16672620,23180473,12354229, 23764491</pubmed> | |
+ | |||
+ | [[Category:Protein-coding genes]] |
Latest revision as of 11:45, 8 April 2014
- Description: elemental iron uptake system (permease), high affinity uptake of ferric iron (Fe(III))
Gene name | ywbL |
Synonyms | ipa-27d |
Essential | no |
Product | elemental iron uptake system (permease) |
Function | elemental iron uptake |
Gene expression levels in SubtiExpress: efeU | |
Interactions involving this protein in SubtInteract: EfeU | |
Metabolic function and regulation of this protein in SubtiPathways: EfeU | |
MW, pI | 52 kDa, 8.958 |
Gene length, protein length | 1443 bp, 481 aa |
Immediate neighbours | efeO, thiE |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
transporters/ other, acquisition of iron, iron metabolism, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU38280
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P39595
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Marcus Miethke, Carmine G Monteferrante, Mohamed A Marahiel, Jan Maarten van Dijl
The Bacillus subtilis EfeUOB transporter is essential for high-affinity acquisition of ferrous and ferric iron.
Biochim Biophys Acta: 2013, 1833(10);2267-78
[PubMed:23764491]
[WorldCat.org]
[DOI]
(P p)
Carmine G Monteferrante, Calum MacKichan, Elodie Marchadier, Maria-Victoria Prejean, Rut Carballido-López, Jan Maarten van Dijl
Mapping the twin-arginine protein translocation network of Bacillus subtilis.
Proteomics: 2013, 13(5);800-11
[PubMed:23180473]
[WorldCat.org]
[DOI]
(I p)
Juliane Ollinger, Kyung-Bok Song, Haike Antelmann, Michael Hecker, John D Helmann
Role of the Fur regulon in iron transport in Bacillus subtilis.
J Bacteriol: 2006, 188(10);3664-73
[PubMed:16672620]
[WorldCat.org]
[DOI]
(P p)
Noel Baichoo, Tao Wang, Rick Ye, John D Helmann
Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon.
Mol Microbiol: 2002, 45(6);1613-29
[PubMed:12354229]
[WorldCat.org]
[DOI]
(P p)