sipV

sipV
168

signal peptidase I

Locus
BSU_10490
Molecular weight
18.81 kDa
Isoelectric point
10.12
Protein length
168 aaSequenceBlast
Gene length
507 bpSequenceBlast
Function
protein secretion
Product
signal peptidase I
Essential
no
Synonyms
sipV, yhjF
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0681 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,122,175  1,122,681
The protein
Catalyzed reaction/ biological activity
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to UniProt)
Protein family
peptidase S26 family (according to Uniprot)
Structure
4NV4 (PDB) (from B. anthracis, 47% identity)
O07560 (AlphaFold)
Paralogous protein(s)
SipT, SipS, SipU
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
yhjE-sipV
Description
PubMed
Regulation
induced upon DNA damage (LexA) PubMed
Regulatory mechanism
LexA: repression, PubMed, in lexA regulon
Open in new tab

yhjE→sipV

2025-04-06 06:41:55

Jstuelk

82

fc8b7e81e7d18b9b493e11b8a6d0ef160dd1bcf5

70E73436169583754454CA49103BB5318623E4A3

Biological materials
Mutant
BKE10490 (sipV::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTTACTGTCTCCCTCCA,  downstream forward: _UP4_TAAAAAGACGCTAATTGAAG
BKK10490 (sipV::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTTACTGTCTCCCTCCA,  downstream forward: _UP4_TAAAAAGACGCTAATTGAAG
Labs working on this gene/protein
Jan Maarten van Dijl, Groningen, Netherlands
References
Reviews
Harwood CR, Kikuchi YThe ins and outs of Bacillus proteases: activities, functions and commercial significance.FEMS microbiology reviews. 2021 Aug 19; . PMID: 34410368
Dalbey RE, Wang P, van Dijl JM Membrane proteases in the bacterial protein secretion and quality control pathway. Microbiology and molecular biology reviews : MMBR. 2012 Jun; 76(2):311-30. doi:10.1128/MMBR.05019-11. PMID:22688815
Original Publications
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Page visits: 2470

Time of last update: 2025-04-10 08:51:42

Author of last update: Jstuelk