lspA
168

signal peptidase II

Locus

BSU_15450

Molecular weight

17.28 kDa

Isoelectric point

9.13

Protein length

154 aaSequenceBlast

Gene length

465 bpSequenceBlast

Function

protein secretion

Product

signal peptidase II

Essential

E.C.

3.4.23.36

Synonyms

lspA, lsp

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0597 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

1,616,744 1,617,208

The protein

Catalyzed reaction/ biological activity

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains (according to UniProt)

Protein family

peptidase A8 family (single member, according to UniProt)

Structure

5DIR (PDB) (from Pseudomonas aeruginosa, 38% identity), PubMed

Q45479 (AlphaFold)

Localization

cell membrane (according to UniProt)

Expression and Regulation

Operons

Genes

lspA-rluD-pyrR

Description