Difference between revisions of "UppS"

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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU16530 uppS]
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU16530 uppS]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=UppS UppS]'''
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.408   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.408   

Revision as of 11:43, 8 April 2014

  • Description: undecaprenyl pyrophosphate synthetase, provides the precursor for the carrier lipid, undecaprenyl phosphate (C55-P), which is required for cell wall synthesis

Gene name uppS
Synonyms yluA
Essential yes PubMed
Product undecaprenyl pyrophosphate synthetase
Function cell wall biosynthesis
Gene expression levels in SubtiExpress: uppS
Metabolic function and regulation of this protein in SubtiPathways:
UppS
MW, pI 29 kDa, 5.408
Gene length, protein length 780 bp, 260 aa
Immediate neighbours frr, cdsA
Sequences Protein DNA DNA_with_flanks
Genetic context
UppS context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
UppS expression.png















Categories containing this gene/protein

cell wall synthesis, biosynthesis of lipids, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU16530

Phenotypes of a mutant

  • essential PubMed
  • the uppS86 (C257T) mutation provides resistance to rare earth metals such as scandium and to bacitracin PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: catalyzes eight consecutive condensation reactions of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to form undecaprenyl pyrophosphate
  • Protein family: UPP synthetase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1X09 (the protein from E. coli, 49% identity, 77% similarity) PubMed
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References