rocC

rocC
168

amino acid permease, major transporter for arginine

Locus
BSU_37760
Molecular weight
51.56 kDa
Isoelectric point
8.41
Protein length
470 aaSequenceBlast
Gene length
1413 bpSequenceBlast
Function
arginine, ornithine and citrulline uptake
Product
major transporter for arginine
Essential
no
Synonyms
rocC, ipa-78d
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0833 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,875,780  3,877,192
The protein
Catalyzed reaction/ biological activity
uptake of arginine PubMed
Protein family
amino acid-polyamine-organocation (APC) superfamily (according to UniProt)
Structure
6F34 (PDB) (from Geobacillus kaustophilus, 24% identity) PubMed
P39636 (AlphaFold)
Paralogous protein(s)
RocE, YbgF, YdgF, AapA, GabP, AlaP, HutM, YvbW, AimB
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
rocA-rocB-rocC
Description
PubMed
Regulation
expression during spore germination is strongly reduced under conditions of osmotic stress PubMed
induced in the presence of arginine (AhrC) PubMed
induced in the presence of arginine, citrulline or ornithine (with ornithine as the molecular inducer) (RocR) PubMed
Regulatory mechanism
CodY: repression, PubMed, in codY regulon
RocR: activation, PubMed, in rocR regulon
AhrC: activation, PubMed, in ahrC regulon
AbrB: repression, PubMed, in abrB regulon
Sigma factors
SigL: sigma factor, PubMed, in sigL regulon
Additional information
expression of the rocA-rocB-rocC operon is increased upon depletion of nusA (resulting from increased ahrC expression) Reference
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rocA→rocC

2025-03-18 21:34:11

Jstuelk

141

2DC790ED3D8C4B63BB982C1F1D977B49CCE4042B

BCA34B2E2917A99583D79922F2E2CBC45D25A78E

Biological materials
Mutant
GP4151 (ΔrocC::aphA3), available in Jörg Stülke's lab
GP4156 (ΔrocC::aphA3, ΔartP-artQ-artR::ermC, ΔrocE::tet,), available in Jörg Stülke's lab
BKE37760 (rocC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAATTCATTTTTATGATTCT,  downstream forward: _UP4_TAGAAAAAGCTCTCCGGGAG
BKK37760 (rocC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAATTCATTTTTATGATTCT,  downstream forward: _UP4_TAGAAAAAGCTCTCCGGGAG
References
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9BFB16C12B31ABD70BBB921BCB9E4201E3BDC92D

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Time of last update: 2025-04-04 05:13:10

Author of last update: Jstuelk