fisB

fisB
168

membrane fission protein, mediates membrane fission during sporulation

Locus
BSU_32350
Molecular weight
27.76 kDa
Isoelectric point
9.53
Protein length
254 aaSequenceBlast
Gene length
765 bpSequenceBlast
Function
release of the forespore into the mother cell cytoplasm
Product
membrane fission protein
Essential
no
E.C.
null
Synonyms
fisB, yunB
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5875 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,322,463  3,323,227
Phenotypes of a mutant
reduced sporulation efficiency (12 - 15%) PubMed
The protein
Catalyzed reaction/ biological activity
mediates membrane fission during sporulation PubMed
binds cardiolipin PubMed
Structure
O32131 (AlphaFold)
Localization
cell membrane PubMed
forms dynamic foci which become immobilized at the site of membrane fission PubMed
Expression and Regulation
Operons
Genes
fisB
Description
PubMed
Regulation
expressed early during sporulation in the mother cell (SigE) PubMed
Sigma factors
SigE: sigma factor, PubMed, in sigE regulon
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fisB

2025-04-03 12:27:33

ghost

123

81aa45bdc7de7e118de92fcd4b378e78c8e1186e

B3F36E1D6103A1ACA0FB1B58D9A56E4BBC8DA359

Biological materials
Mutant
MGNA-A978 (yunB::erm), available at the NBRP B. subtilis, Japan
BKE32350 (fisB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAGAAAATCCCCCCTTACA,  downstream forward: _UP4_TAAGCCGCCTGTTGAAGAGG
BKK32350 (fisB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAGAAAATCCCCCCTTACA,  downstream forward: _UP4_TAAGCCGCCTGTTGAAGAGG
References
Reviews
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Original Publications
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Time of last update: 2025-04-16 08:00:43

Author of last update: Jstuelk