nupP

nupP
168

ABC transporter for guanosine (membrane protein)

Locus
BSU_31560
Molecular weight
36.69 kDa
Isoelectric point
9.39
Protein length
348 aaSequenceBlast
Gene length
1047 bpSequenceBlast
Function
uptake of guanosine
Product
ABC transporter for guanosine
Essential
no
Synonyms
nupP, yufP
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4603 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,242,610  3,243,656
The protein
Protein family
Binding-protein-dependent transport system permease family (according to UniProt)
Structure
O05254 (AlphaFold)
Localization
cell membrane PubMed
Expression and Regulation
Operons
Genes
nupN-nupO-nupP-nupQ
Description
PubMed
Regulation
repressed during growth in the presence of branched chain amino acids (CodY) PubMed
Regulatory mechanism
CodY: repression, PubMed, in codY regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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nupN→nupQ

2025-03-16 18:04:09

ghost

87

176c32eb4a5e0c99af55c2dcae84f2d09f6ef942

1A88DAA8C1BBE629E7600C276F82763A709A3EA7

Biological materials
Mutant
MGNA-B555 (yufP::erm), available at the NBRP B. subtilis, Japan
BKE31560 (nupP::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GTTTAACCATTTGCTTTCCC,  downstream forward: _UP4_TTGAAGAAAAAGGGGGCGAA
BKK31560 (nupP::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_GTTTAACCATTTGCTTTCCC,  downstream forward: _UP4_TTGAAGAAAAAGGGGGCGAA
References
Mahendran A, Orlando BJGenome wide structural prediction of ABC transporter systems in Bacillus subtilis.Frontiers in microbiology. 2024; 15:1469915. PMID: 39397791
O'Reilly FJ, Graziadei A, Forbrig C, Bremenkamp R, Charles K, Lenz S, Elfmann C, Fischer L, Stülke J, Rappsilber JProtein complexes in cells by AI-assisted structural proteomics.Molecular systems biology. 2023 Feb 23; :e11544. PMID: 36815589
Belitsky BR, Sonenshein AL CodY-mediated regulation of guanosine uptake in Bacillus subtilis. Journal of bacteriology. 2011 Nov; 193(22):6276-87. doi:10.1128/JB.05899-11. PMID:21926227
Molle V, Nakaura Y, Shivers RP, Yamaguchi H, Losick R, Fujita Y, Sonenshein AL Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis. Journal of bacteriology. 2003 Mar; 185(6):1911-22. . PMID:12618455
Quentin Y, Fichant G, Denizot F Inventory, assembly and analysis of Bacillus subtilis ABC transport systems. Journal of molecular biology. 1999 Apr 02; 287(3):467-84. . PMID:10092453

0BB235F189D30C9BE798560C31DA59FF0112CFD9

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Time of last update: 2025-04-04 04:11:07

Author of last update: Jstuelk