Difference between revisions of "FadR"
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU28550&redirect=T BSU28550] | ||
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/lcfA-ysiAB-etfBA.html] | * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/lcfA-ysiAB-etfBA.html] | ||
| Line 91: | Line 92: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU28550&redirect=T BSU28550] | ||
* '''Structure:''' | * '''Structure:''' | ||
Revision as of 14:27, 2 April 2014
- Description: transcriptional repressor (TetR family), regulation of fatty acid degradation
| Gene name | fadR |
| Synonyms | ysiA |
| Essential | no |
| Product | transcriptional repressor |
| Function | regulation of fatty acid degradation |
| Gene expression levels in SubtiExpress: fadR | |
| Metabolic function and regulation of this protein in SubtiPathways: fadR | |
| MW, pI | 21 kDa, 6.118 |
| Gene length, protein length | 582 bp, 194 aa |
| Immediate neighbours | fadB, lcfA |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
utilization of lipids, transcription factors and their control
This gene is a member of the following regulons
The FadR regulon
The gene
Basic information
- Locus tag: BSU28550
Phenotypes of a mutant
Database entries
- BsubCyc: BSU28550
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: TetR family
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity: long chain fatty acids act as inducers that release FadR from its operator sites PubMed
Database entries
- BsubCyc: BSU28550
- Structure:
- UniProt: P94548
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- induced by long-chain fatty acids (FadR) PubMed
- subject to carbon catabolite repression (CcpA-HPr(Ser-P) PubMed
- Regulatory mechanism:
- FadR: transcription repression PubMed
- CcpA-HPr(Ser-P): transcription repression PubMed
- Additional information:
Biological materials
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Leslie Cuthbertson, Justin R Nodwell
The TetR family of regulators.
Microbiol Mol Biol Rev: 2013, 77(3);440-75
[PubMed:24006471]
[WorldCat.org]
[DOI]
(I p)
Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287]
[WorldCat.org]
[DOI]
(P p)
Original publications
Masahiro Fujihashi, Taiga Nakatani, Kazutake Hirooka, Hiroshi Matsuoka, Yasutaro Fujita, Kunio Miki
Structural characterization of a ligand-bound form of Bacillus subtilis FadR involved in the regulation of fatty acid degradation.
Proteins: 2014, 82(7);1301-10
[PubMed:24356978]
[WorldCat.org]
[DOI]
(I p)
Shigeo Tojo, Takenori Satomura, Hiroshi Matsuoka, Kazutake Hirooka, Yasutaro Fujita
Catabolite repression of the Bacillus subtilis FadR regulon, which is involved in fatty acid catabolism.
J Bacteriol: 2011, 193(10);2388-95
[PubMed:21398533]
[WorldCat.org]
[DOI]
(I p)
Hiroshi Matsuoka, Kazutake Hirooka, Yasutaro Fujita
Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation.
J Biol Chem: 2007, 282(8);5180-94
[PubMed:17189250]
[WorldCat.org]
[DOI]
(P p)
