CorA

• Description: general stress protein, similar to magnesium transporter
  
  

Gene name	corA
Synonyms	yqhC , yqxL
Essential	no
Product	unknown
Function	unknown
Gene expression levels in SubtiExpress: corA
Metabolic function and regulation of this protein in SubtiPathways: metal ion homeostasis
MW, pI	37 kDa, 9.536
Gene length, protein length	951 bp, 317 aa
Immediate neighbours	comGA, yqhB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, metal ion homeostasis (K, Na, Ca, Mg), general stress proteins (controlled by SigB), membrane proteins

This gene is a member of the following regulons

LexA regulon, SigB regulon

The gene

Basic information

• Locus tag: BSU24740

Database entries

• BsubCyc: BSU24740

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • there is no indication for an implication of CorA in Mg²⁺ uptake (based on mutant phenotypes, failure to complement mutants defective in Mg²⁺ uptake) PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU24740

• Structure:

• UniProt: P40948

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: corA PubMed

• Expression browser: corA PubMed

• Sigma factor: SigB PubMed

• Regulation:
  • induced by stress (SigB) PubMed
  • induced upon DNA damage (LexA) PubMed

• Regulatory mechanism:
  • LexA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Catherine A Wakeman, Jonathan R Goodson, Vineetha M Zacharia, Wade C Winkler
Assessment of the requirements for magnesium transporters in Bacillus subtilis.
J Bacteriol: 2014, 196(6);1206-14
[PubMed:24415722] [WorldCat.org] [DOI] (I p)

Nora Au, Elke Kuester-Schoeck, Veena Mandava, Laura E Bothwell, Susan P Canny, Karen Chachu, Sierra A Colavito, Shakierah N Fuller, Eli S Groban, Laura A Hensley, Theresa C O'Brien, Amish Shah, Jessica T Tierney, Louise L Tomm, Thomas M O'Gara, Alexi I Goranov, Alan D Grossman, Charles M Lovett
Genetic composition of the Bacillus subtilis SOS system.
J Bacteriol: 2005, 187(22);7655-66
[PubMed:16267290] [WorldCat.org] [DOI] (P p)

Hanne-Leena Hyyryläinen, Matti Sarvas, Vesa P Kontinen
Transcriptome analysis of the secretion stress response of Bacillus subtilis.
Appl Microbiol Biotechnol: 2005, 67(3);389-96
[PubMed:15856219] [WorldCat.org] [DOI] (P p)

Dirk Höper, Uwe Völker, Michael Hecker
Comprehensive characterization of the contribution of individual SigB-dependent general stress genes to stress resistance of Bacillus subtilis.
J Bacteriol: 2005, 187(8);2810-26
[PubMed:15805528] [WorldCat.org] [DOI] (P p)

Mary Ann Warren, Lisa M Kucharski, Alexander Veenstra, Liang Shi, Paul F Grulich, Michael E Maguire
The CorA Mg2+ transporter is a homotetramer.
J Bacteriol: 2004, 186(14);4605-12
[PubMed:15231793] [WorldCat.org] [DOI] (P p)

M Albano, R Breitling, D A Dubnau
Nucleotide sequence and genetic organization of the Bacillus subtilis comG operon.
J Bacteriol: 1989, 171(10);5386-404
[PubMed:2507524] [WorldCat.org] [DOI] (P p)