dnaD

dnaD
168

initiation of chromosome replication, part of the replisome

Locus
BSU_22350
Molecular weight
27.49 kDa
Isoelectric point
7.17
Protein length
232 aaSequenceBlast
Gene length
699 bpSequenceBlast
Function
DNA replication
Product
initiation of chromosome replication
Essential
yes
Synonyms
dnaD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG3935 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,345,433 → 2,346,131
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
binds a ssDNA motif in oriC PubMed
DnaD-mediated untwisting of the DNA stimulates Nth endonuclease activity at AP sites PubMed
required for the assembly of the replicative helicase DnaC at the origin of replication PubMed
interaction with DnaA inhibits the ability of DnaA to bind cooperatively to DNA PubMed
Structure
2C79 (PDB) (N-terminal domain)
P39787 (AlphaFold)
Localization
Membrane-proximal (Spotty) PubMed
Expression and Regulation
Operons
Genes
asnS-dnaD-nth-ypoC
Description
PubMed
Open in new tab

asnS→ypoC

2025-04-03 07:01:27

Jstuelk

131

bddd14432a7dcf7c9a63e653f673da9509b2f9e3

2131D7452E334EEE4F3058582EAA4C1674387033

Genes
dnaD-nth
Description
PubMed
Regulation
constitutively expressed PubMed
Open in new tab

dnaD→nth

2025-04-03 06:57:59

ghost

113

65d592657688b69134681e5f3b8625d248b380d2

2611FA0607D22ABE843DF3A9F08C088FA9A52577

Labs working on this gene/protein
Alan Grossman, MIT, Cambridge, MA, USA
References
Reviews
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Original Publications
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C9FEE07601AD28B2651EB881A1D9B34D5082237C

Page visits: 5957

Time of last update: 2025-04-13 07:29:54

Author of last update: Jstuelk