polC

polC
168

DNA polymerase III, leading strand polymerase (alpha subunit), part of the replisome

Locus
BSU_16580
Molecular weight
162.42 kDa
Isoelectric point
5.14
Protein length
1437 aaSequenceBlast
Gene length
4311 bpSequenceBlast
Function
DNA replication
Product
DNA polymerase III (alpha subunit)
Essential
yes
E.C.
2.7.7.7
Synonyms
polC, mutI, dnaF, dnaP
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2176 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,727,133 → 1,731,446
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
2'-deoxyribonucleoside 5'-triphosphate + DNA(n) --> diphosphate + DNA(n+1) (according to UniProt)
required for bacteriophage SPP1 replication PubMed
Protein family
DNA polymerase type-C family (with YorL and DnaE, according to UniProt)
Domains
Exonuclease domain (aa 421-578) (according to UniProt)
Structure
3F2B (PDB) (from Geobacillus kaustophilus, 71% identity) PubMed
P13267 (AlphaFold)
Localization
forms foci PubMed
about three molecules of PolC at each replication fork PubMed
Expression and Regulation
Operons
Genes
ispC-rasP-proS-polC
Description
PubMed
Open in new tab

ispC→polC

2025-04-22 16:10:10

Jstuelk

151

babdb9046d2f2d5bae4dac8092e2f7235f01c3e9

23B0B9EE13D6BD9F4D99911E7AA88933F4080154

Genes
uppS-cdsA-ispC-rasP-proS-polC
Description
PubMed
Open in new tab

uppS→polC

2025-04-04 04:32:05

Jstuelk

143

c6a20b58d42a343484ae9ff8f9312018bf0f82f2

3AF78B34597AE93B1AF63769A0A2561D91069003

Additional information
about 60 molecules per cell PubMed
References
Reviews
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Original Publications
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FB97DF0C147FB29944F60214CB9BC1803861DAA0

Page visits: 5221

Time of last update: 2025-04-23 00:46:03

Author of last update: Jstuelk