Difference between revisions of "FabG"

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=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU15910&redirect=T BSU15910]
  
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/fapR-plsX-fabDG.html]
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/fapR-plsX-fabDG.html]
Line 99: Line 100:
  
 
=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU15910&redirect=T BSU15910]
  
 
* '''Structure:''' [http://www.rcsb.org/pdb/explore/explore.do?structureId=1I01 1I01] (the enzyme from ''E. coli'') {{PubMed|11669613}}  
 
* '''Structure:''' [http://www.rcsb.org/pdb/explore/explore.do?structureId=1I01 1I01] (the enzyme from ''E. coli'') {{PubMed|11669613}}  

Revision as of 13:42, 2 April 2014

  • Description: beta-ketoacyl-acyl carrier protein reductase

Gene name fabG
Synonyms ylpF
Essential yes PubMed
Product beta-ketoacyl-acyl carrier protein reductase
Function fatty acid biosynthesis
Gene expression levels in SubtiExpress: fabG
Metabolic function and regulation of this protein in SubtiPathways:
fabG
MW, pI 26 kDa, 8.091
Gene length, protein length 738 bp, 246 aa
Immediate neighbours fabD, acpA
Sequences Protein DNA DNA_with_flanks
Genetic context
FabG context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
FabG expression.png




























Categories containing this gene/protein

biosynthesis of lipids, essential genes

This gene is a member of the following regulons

ComA regulon, FapR regulon

The gene

Basic information

  • Locus tag: BSU15910

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH (according to Swiss-Prot)
  • Protein family: short-chain dehydrogenases/reductases (SDR) family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1I01 (the enzyme from E. coli) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • induced if the cells experience an accumulation of malonyl-CoA (FapR) PubMed
    • expressed at high cell density (ComA) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287] [WorldCat.org] [DOI] (P p)

Stephen W White, Jie Zheng, Yong-Mei Zhang, Rock
The structural biology of type II fatty acid biosynthesis.
Annu Rev Biochem: 2005, 74;791-831
[PubMed:15952903] [WorldCat.org] [DOI] (P p)

Original Publications