NatA

• Description: Na+ ABC transporter (export) (ATP-binding protein)
  
  

Gene name	natA
Synonyms
Essential	no
Product	Na+ ABC transporter (export) (ATP-binding protein)
Function	sodium export
Gene expression levels in SubtiExpress: natA
Interactions involving this protein in SubtInteract: NatA
MW, pI	27 kDa, 8.799
Gene length, protein length	738 bp, 246 aa
Immediate neighbours	natR, natB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, metal ion homeostasis (K, Na, Ca, Mg), membrane proteins

This gene is a member of the following regulons

NatR regulon

The gene

Basic information

• Locus tag: BSU02750

Database entries

• BsubCyc: BSU02750
• BsubCyc: BSU02750

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ABC transporter domain (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • NatA-NatB PubMed

• Localization: membrane associated (via NatB) PubMed

Database entries

• BsubCyc: BSU02750
• BsubCyc: BSU02750

• Structure:

• UniProt: P46903

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: natA-natB PubMed

• Expression browser: natA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism: NatR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Mitsuo Ogura, Kensuke Tsukahara, Kentaro Hayashi, Teruo Tanaka
The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
Microbiology (Reading): 2007, 153(Pt 3);667-675
[PubMed:17322186] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)

J Cheng, A A Guffanti, T A Krulwich
A two-gene ABC-type transport system that extrudes Na+ in Bacillus subtilis is induced by ethanol or protonophore.
Mol Microbiol: 1997, 23(6);1107-20
[PubMed:9106203] [WorldCat.org] [DOI] (P p)