PlsC

• Description: acyl-ACP:1-acylglycerolphosphate acyltransferase
  
  

Gene name	plsC
Synonyms	yhdO
Essential	yes PubMed
Product	acyl-ACP:1-acylglycerolphosphate acyltransferase
Function	biosynthesis of phospholipids
Gene expression levels in SubtiExpress: plsC
Metabolic function and regulation of this protein in SubtiPathways: plsC
MW, pI	21 kDa, 9.976
Gene length, protein length	597 bp, 199 aa
Immediate neighbours	yhdN, yhdP
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of lipids, general stress proteins (controlled by SigB), essential genes, membrane proteins

This gene is a member of the following regulons

FapR regulon, SigB regulon

The gene

Basic information

• Locus tag: BSU09540

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU09540

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane at the septum PubMed

Database entries

• BsubCyc: BSU09540

• Structure:

• UniProt: O07584

• KEGG entry: [3]

• E.C. number: 2.3.1.51

Expression and regulation

• Operon: yhdN-plsC PubMed

• Expression browser: plsC PubMed

• Sigma factor: SigB PubMed

• Regulation:
  • induced by stress (SigB) PubMed
  • induced upon malonyl-CoA limitation (FapR) PubMed

• Regulatory mechanism:
  • FapR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Lucía Porrini, Larisa E Cybulski, Silvia G Altabe, María C Mansilla, Diego de Mendoza
Cerulenin inhibits unsaturated fatty acids synthesis in Bacillus subtilis by modifying the input signal of DesK thermosensor.
Microbiologyopen: 2014, 3(2);213-24
[PubMed:24574048] [WorldCat.org] [DOI] (I p)

Luciana Paoletti, Ying-Jie Lu, Gustavo E Schujman, Diego de Mendoza, Charles O Rock
Coupling of fatty acid and phospholipid synthesis in Bacillus subtilis.
J Bacteriol: 2007, 189(16);5816-24
[PubMed:17557823] [WorldCat.org] [DOI] (P p)

Ayako Nishibori, Jin Kusaka, Hiroshi Hara, Masato Umeda, Kouji Matsumoto
Phosphatidylethanolamine domains and localization of phospholipid synthases in Bacillus subtilis membranes.
J Bacteriol: 2005, 187(6);2163-74
[PubMed:15743965] [WorldCat.org] [DOI] (P p)

Gustavo E Schujman, Luciana Paoletti, Alan D Grossman, Diego de Mendoza
FapR, a bacterial transcription factor involved in global regulation of membrane lipid biosynthesis.
Dev Cell: 2003, 4(5);663-72
[PubMed:12737802] [WorldCat.org] [DOI] (P p)