rapJ
168

response regulator aspartate phosphatase, dephosphorylates Spo0F-P

Locus

BSU_02820

Molecular weight

44.25 kDa

Isoelectric point

4.9

Protein length

373 aaSequenceBlast

Gene length

1122 bpSequenceBlast

Function

control of the phosphorelay

Product

response regulator aspartate phosphatase

Essential

Synonyms

rapJ, ycdE

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0457 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

304,430 → 305,551

The protein

Catalyzed reaction/ biological activity

dephosphorylates Spo0F-P PubMed

Protein family

RAP family (according to UniProt)

Domains

RapJ is made up of the C-terminal tetratricopeptide repeat (TPR) domain (five tetratrichopeptide repeats) that is connected by a flexible helix containing linker to the N-terminal 3-helix bundle. Upon binding of the regulating peptide PhrC, the 3-helix bundle and the linker helix undergo a conformational change to form a TPR-like fold that merges with the existing C-terminal TPR domain. PubMed

Structure

4GYO (PDB) (complex RapJ-PhrC) PubMed

O34327 (AlphaFold)

Effectors of protein activity

the interaction with PhrC inactivates RapJ PubMed

Expression and Regulation

Operons

Genes

rapJ

Description

PubMed

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