ybbA

ybbA
168

enterobactin esterase, release of iron from enterobactin

Locus
BSU_01600
Molecular weight
21.37 kDa
Isoelectric point
7.91
Protein length
250 aaSequenceBlast
Gene length
753 bpSequenceBlast
Function
iron acquisition from enterobactin PubMed
Product
enterobactin esterase PubMed
Essential
no
Synonyms
ybbA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms, belongs to COG2819 (Galperin et al., 2021)

This gene is a member of the following regulons

SigA regulon, Fur regulon, Btr regulon

Gene
Coordinates
179,595  180,347
The protein
Structure
1GKL (PDB) (esterase from Clostridium thermocellum, 21% identity) PubMed
P55192 (AlphaFold)
Expression and Regulation
Operons
Genes
feuA-feuB-feuC-ybbA
Description
PubMed
Regulation
expression during spore germination is strongly reduced under conditions of osmotic stress PubMed
induced by iron starvation (second wave to allow iron scavenging from the environment) (Fur) PubMed
Regulatory mechanism
Fur: repression, PubMed, in fur regulon
Btr: activation, in the presence of the co-activators bacillibactin or enterobactin PubMed, in btr regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Additional information
the presence of an iron-responsive element bound by CitB between ''feuA and feuB'' suggests iron-dependent regulation by CitB PubMed
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feuA→ybbA

2025-03-16 16:54:39

Jstuelk

118

c6ed9c562a4c7db452ebc8903a1989d0bb2f0947

A3C1B309E9C3034B9896B74BA25621D2CF69902F

Other regulations
CitB: translation control
Biological materials
Mutant
BKE01600 (ybbA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTTGTGTTCTGAAAGAGATC,  downstream forward: _UP4_CGCTCAACCCTATGAGCGGT
BKK01600 (ybbA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTTGTGTTCTGAAAGAGATC,  downstream forward: _UP4_CGCTCAACCCTATGAGCGGT
References
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Time of last update: 2025-04-06 03:29:21

Author of last update: Jstuelk