Difference between revisions of "FolK"

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=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU00790&redirect=T BSU00790]
  
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/pabBAC-sul-folBK-yazB-yacF-lysS.html]
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/pabBAC-sul-folBK-yazB-yacF-lysS.html]
Line 95: Line 96:
  
 
=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU00790&redirect=T BSU00790]
  
 
* '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1IM6 1IM6] (from ''Escherichia coli'', 47% identity, 61% similarity) {{PubMed|12578370}}
 
* '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1IM6 1IM6] (from ''Escherichia coli'', 47% identity, 61% similarity) {{PubMed|12578370}}

Revision as of 12:47, 2 April 2014

  • Description: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

Gene name folK
Synonyms
Essential no
Product 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
Function biosynthesis of folate
Gene expression levels in SubtiExpress: folK
Metabolic function and regulation of this protein in SubtiPathways:
folK
MW, pI 18 kDa, 4.531
Gene length, protein length 501 bp, 167 aa
Immediate neighbours folB, yazB
Sequences Protein DNA DNA_with_flanks
Genetic context
FolK context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
FolK expression.png




























Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU00790

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate (according to Swiss-Prot)
  • Protein family: HPPK family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1IM6 (from Escherichia coli, 47% identity, 61% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References