Difference between revisions of "DltD"

From SubtiWiki
Jump to: navigation, search
Line 66: Line 66:
  
 
=== Additional information===
 
=== Additional information===
 
 
 
  
 
=The protein=
 
=The protein=
Line 84: Line 81:
 
* '''Kinetic information:'''
 
* '''Kinetic information:'''
  
* '''Domains:'''  
+
* '''[[Domains]]:'''  
  
 
* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):'''
+
* '''[[Cofactors]]:'''
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
Line 98: Line 95:
 
=== Database entries ===
 
=== Database entries ===
  
* '''Structure:'''
+
* '''Structure:''' [http://www.pdb.org/pdb/explore/explore.do?structureId=3bma 3BMA] (from ''Streptococcus pneumoniae'', 26% identity)
  
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/P39578 P39578]
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/P39578 P39578]

Revision as of 16:52, 27 February 2014

  • Description: D-alanine transfer from undecaprenol-phosphate to the poly(glycerophosphate) chain, alanylation of teichoic acid provides some resistance against positively charged antimicrobial peptides

Gene name dltD
Synonyms ipa-2r
Essential no
Product D-alanine transfer from undecaprenol-phosphate
to the poly(glycerophosphate) chain
Function biosynthesis of teichoic acid
Gene expression levels in SubtiExpress: dltD
MW, pI 44 kDa, 9.858
Gene length, protein length 1176 bp, 392 aa
Immediate neighbours dltC, dltE
Sequences Protein DNA DNA_with_flanks
Genetic context
DltD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
DltD expression.png















Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, cell envelope stress proteins (controlled by SigM, V, W, X, Y)

This gene is a member of the following regulons

SigD regulon, SigM regulon, SigX regulon, Spo0A regulon, stringent response, YvrHb regulon

The gene

Basic information

  • Locus tag: BSU38530

Phenotypes of a mutant

  • more sensitive to nisin PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure: 3BMA (from Streptococcus pneumoniae, 26% identity)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • RelA dependent downregulation (Class I) during stringent response PubMed
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
    • expression is reduced in a SigV mutant PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References