Difference between revisions of "DapB"
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= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
| + | {{SubtiWiki category|[[cell wall synthesis]]}}, | ||
{{SubtiWiki category|[[biosynthesis/ acquisition of amino acids]]}}, | {{SubtiWiki category|[[biosynthesis/ acquisition of amino acids]]}}, | ||
| + | {{SubtiWiki category|[[Biosynthesis of cell wall components]]}}, | ||
{{SubtiWiki category|[[essential genes]]}} | {{SubtiWiki category|[[essential genes]]}} | ||
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=== Additional information=== | === Additional information=== | ||
| − | |||
| − | |||
| − | |||
=The protein= | =The protein= | ||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' 2,3,4,5-tetrahydrodipicolinate + | + | * '''Catalyzed reaction/ biological activity:''' 2,3,4,5-tetrahydrodipicolinate + NADP<sup>+</sup> = 2,3-dihydrodipicolinate + NADPH (according to Swiss-Prot) |
* '''Protein family:''' glucose-6-phosphate dehydrogenase family (according to Swiss-Prot) | * '''Protein family:''' glucose-6-phosphate dehydrogenase family (according to Swiss-Prot) | ||
| Line 82: | Line 81: | ||
* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' NADP<sup>+</sup> |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
Revision as of 11:45, 5 January 2014
- Description: dihydrodipicolinate reductase (NADPH)
| Gene name | dapB |
| Synonyms | |
| Essential | yes PubMed |
| Product | dihydrodipicolinate reductase (NADPH) |
| Function | biosynthesis of lysine and peptidoglycan |
| Gene expression levels in SubtiExpress: dapB | |
| Metabolic function and regulation of this protein in SubtiPathways: Lys, Thr | |
| MW, pI | 29 kDa, 5.057 |
| Gene length, protein length | 801 bp, 267 aa |
| Immediate neighbours | mgsA, ypjD |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
cell wall synthesis, biosynthesis/ acquisition of amino acids, Biosynthesis of cell wall components, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU22490
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH (according to Swiss-Prot)
- Protein family: glucose-6-phosphate dehydrogenase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Cofactors: NADP+
- Effectors of protein activity:
Database entries
- UniProt: P42976
- KEGG entry: [2]
- E.C. number: 1.3.1.26
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Operon and expression
Ahmed Gaballa, Haike Antelmann, Chris J Hamilton, John D Helmann
Regulation of Bacillus subtilis bacillithiol biosynthesis operons by Spx.
Microbiology (Reading): 2013, 159(Pt 10);2025-2035
[PubMed:23894131]
[WorldCat.org]
[DOI]
(I p)
Ahmed Gaballa, Gerald L Newton, Haike Antelmann, Derek Parsonage, Heather Upton, Mamta Rawat, Al Claiborne, Robert C Fahey, John D Helmann
Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.
Proc Natl Acad Sci U S A: 2010, 107(14);6482-6
[PubMed:20308541]
[WorldCat.org]
[DOI]
(I p)
