Difference between revisions of "FadR"
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=== Additional information=== | === Additional information=== | ||
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
| − | * '''Effectors of protein activity:''' long chain fatty acids act as inducers that release FadR from its operator sites | + | * '''Effectors of protein activity:''' long chain fatty acids act as inducers that release FadR from its operator sites {{PubMed|24356978}} |
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
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<pubmed>17919287, 24006471 </pubmed> | <pubmed>17919287, 24006471 </pubmed> | ||
==Original publications== | ==Original publications== | ||
| − | <pubmed>17189250,21398533</pubmed> | + | <pubmed>17189250,21398533 24356978</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 15:23, 27 December 2013
- Description: transcriptional repressor (TetR family), regulation of fatty acid degradation
| Gene name | fadR |
| Synonyms | ysiA |
| Essential | no |
| Product | transcriptional repressor |
| Function | regulation of fatty acid degradation |
| Gene expression levels in SubtiExpress: fadR | |
| Metabolic function and regulation of this protein in SubtiPathways: Fatty acid degradation | |
| MW, pI | 21 kDa, 6.118 |
| Gene length, protein length | 582 bp, 194 aa |
| Immediate neighbours | fadB, lcfA |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
utilization of lipids, transcription factors and their control
This gene is a member of the following regulons
The FadR regulon
The gene
Basic information
- Locus tag: BSU28550
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: TetR family
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity: long chain fatty acids act as inducers that release FadR from its operator sites PubMed
Database entries
- Structure:
- UniProt: P94548
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- induced by long-chain fatty acids (FadR) PubMed
- subject to carbon catabolite repression (CcpA-HPr(Ser-P) PubMed
- Regulatory mechanism:
- FadR: transcription repression PubMed
- CcpA-HPr(Ser-P): transcription repression PubMed
- Additional information:
Biological materials
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Leslie Cuthbertson, Justin R Nodwell
The TetR family of regulators.
Microbiol Mol Biol Rev: 2013, 77(3);440-75
[PubMed:24006471]
[WorldCat.org]
[DOI]
(I p)
Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287]
[WorldCat.org]
[DOI]
(P p)
Original publications
